University of Guam/Cancer Research Center of Hawaii Partnership (1 of 2)

关岛大学/夏威夷癌症研究中心合作伙伴（1 of 2）

• 批准号: 7939681
• 负责人: CARL-WILHELM E VOGEL
• 金额: $ 84.63万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-28 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7939681
• 关键词: University; Guam; Cancer; Research; Center

DESCRIPTION (provided by applicant): Oral cancer is the sixth leading cancer in the world, and ranks in the top three cancers in countries where betel nut (also known as areca nut) chewing is common. In Micronesia, a group of Pacific Islands where betel nut is frequently chewed, the risk of oral cancer is elevated, but quite variable across populations. For the period 1985-1998 (age-adjusted to the 1988 U.S. population), the prevalence per 100,000 ranged from 4.2 in Chuuk to 31.8 in Yap. In Guam, the incidence of mouth cancer per 100,000 population for the period 1997-2003, age-adjusted to the 2000 U.S. population, varied between 8.1 for Chamorros to 17.9 among other Micronesians. The disparity in oral cancer rates among these populations may be due to differences in betel nut chewing patterns. To investigate the effect of chewing patterns, we must be able to conduct studies on multiple Micronesian islands with differing chewing patterns. Previously, we developed a comprehensive betel nut assessment protocol and a protocol for detecting oral lesions on Guam. The overall objectives of the pilot study are to further develop and test these methods, and to demonstrate that they can be applied in a research study of betel nut use on an island other than Guam. A convenience sample of 100 Micronesians (50 men and 50 women) who are long-term betel nut users (regular use for at least 10 years) will be recruited from the island of Saipan in the Commonwealth of the Northern Mariana Islands (CNMI). We will collect data on betel nut use, presence of oral precancerous lesions, diet, demographics, anthropometry, medical history, and physical activity. The specific aims of this study are to: 1) collect information on betel nut use among study participants and other members of their families, 2) perform oral examinations, and biopsies, as needed, on study participants, 3) measure other health risks among this population, including obesity, high blood pressure, self-reported history of cardiovascular disease and diabetes, and unhealthy dietary practices and 4) examine associations of duration, frequency, and type of betel nut use with oral pre-cancers and with other health risks. This pilot project will help formulate the research methods for studying betel nut use and disease risk in Micronesia, and will provide the necessary preliminary data for a full multi-island study of betel nut use and the prevalence of oral lesions. Ultimately, a better understanding of these associations will provide important new directions for reduction of health risks through educational efforts and targeted intervention strategies.

描述（由申请人提供）：口腔癌是世界上第六个领先的癌症，在槟榔（也称为槟榔）咀嚼的国家中排名前三的癌症。在密克罗尼西亚，一群经常咀嚼槟榔的太平洋岛屿，口腔癌的风险升高，但人群之间的差异很大。在1985 - 1998年期间（​​对1988年的美国人口进行了调整），每100,000次的患病率从Chuuk的4.2到YAP的31.8不等。在关岛，1997 - 2003年的每10万人人口的口腔癌发生率，对2000年的美国人口进行了调整，在Chamorros的8.1范围内，在其他MICRONESIAN中，在17.9之间变化。这些人群中口腔癌率的差异可能是由于槟榔咀嚼模式的差异。为了研究咀嚼模式的效果，我们必须能够对具有不同咀嚼模式的多个密克罗尼亚岛进行研究。以前，我们制定了全面的槟榔评估方案和一种用于检测关岛口腔病变的方案。试点研究的总体目标是进一步开发和测试这些方法，并证明可以将它们应用于关岛以外的岛屿上的槟榔使用研究。将从北玛丽安娜群岛（CNMI）的塞班岛（CNMI）的塞班岛招募100名密克罗尼代人（50名男性和50名女性）的便利样本。我们将收集有关槟榔的使用，口腔癌性病变，饮食，人口统计学，人体测量法，病史和体育锻炼的数据。这项研究的具体目的是：1）收集研究参与者及其家庭其他成员之间的槟榔坚果的信息，2）进行口腔检查，以及根据需要进行的，在研究参与者的情况下进行活检，3）衡量该人群中的其他健康风险，包括肥胖，高血压，高血压，自我报道的心血管疾病和糖尿病和糖尿病的效果以及4）类型效果，以及4）类型的类型，以及4）类型的类型，4）与口腔前癌症和其他健康风险有关。该试点项目将有助于制定有关密克罗尼西亚槟榔的使用和疾病风险的研究方法，并将提供必要的初步数据，以进行全面的槟榔使用和口服病变的多种多样研究。最终，对这些协会的更好理解将为通过教育工作和有针对性的干预策略降低健康风险的重要新方向。