Development Research Plan

发展研究计划的目标是确定和支持与 PNWRCE的战略使命。PNWRCE将推进对抗A-C类NIAID的战略 代理商通过制定两个主题：“识别免疫系统中与年龄相关的缺陷 促进疫苗和补充疗法的开发“和”使用系统生物学和 用系统遗传学方法确定病原菌与宿主的相互作用及先天和适应性机制 将鼓励RCE内的科学家和符合条件的地区的科学家提出申请 希望进入生物防御/宰牲节研究的科学家。因此，我们将利用试点项目机制 扩大PNW地区生物防御/EID研究的范围和优势，并开发一种 支持和丰富中心活动的前沿研究组合。提出了三个具体目标来 实现这些目标：(1)征集、确定和支持下列发展研究项目(“试点”项目) 扩大太平洋西北地区(PNW)调查人员的范围和范围，并利用 与PNWRCE主题相关的新想法和新兴技术。(二)支持经济增长 将成功的试点项目转化为独立研究资助，将导致产品开发 (疫苗、治疗或诊断)抗NIAIDA-C病原体或生物防御/EID的关键进展 研究。(三)通过试点机制，打造新兴人才平台和 可以加强或取代现有研究项目的技术，从而为 中心对最有前途的研究方向进行优先排序和推进。我们将使用电子设备 与俄勒冈州既定的翻译研究计划(OCTRI)相关的交流系统 和华盛顿(CTSA)从符合条件的科学家的广泛人才基础中征集申请。根据 在NIAID的政策下，我们将通过一个互动委员会来选择、资助和管理成功的申请 中心科学家、管理人员和外部顾问。我们的使命是保持中心的卓越 通过支持具有高潜力的产品开发和成熟为独立的项目 研究项目。

The goal of the Developmental Research Plan is to identify and support pilot projects that complement the strategic mission of the PNWRCE. The PNWRCE will advance strategies to combat NIAID Category A-C agents via the development of two themes: "Identification of age-related defects in the immune system to facilitate the development of vaccines and supplemental therapies" and "The use of systems biology and systems genetics approaches to define pathogen-host interactions and mechanisms of innate and adaptive immunity." Applications will be encouraged from scientists within the RCE and from eligible regional scientists wishing to move into biodefense/EID research. Thus, we will leverage the pilot project mechanism to expand the scope and excellence of biodefense/EID research in the PNW region and develop a cutting edge research portfolio to sustain and enrich Center's activities. Three Specific Aims are proposed to achieve these goals: (1) To solicit, identify and support developmental research projects ("pilot" projects) that expand the scope and range of investigators within the Pacific Northwest (PNW) region and take advantage of novel ideas and emerging technologies relevant to PNWRCE themes. (2) To support the growth of successful pilot projects into independent research grants that will lead to development of products (vaccines, therapeutics or diagnostics) against NIAID A-C pathogens or key advances in biodefense/EID research. (3) To create, through the pilot project mechanism, a platform of emergent talents and technologies that could enhance or replace existing research projects, thereby creating flexibility for the Center to prioritize and advance in the most promising research directions. We will use electronic communication systems in association with established translational research initiatives in Oregon (OCTRI) and Washington (CTSA) to solicit applications from a broad talent base of eligible scientists. In accordance with NIAID policies, we will select, fund and manage successful applications via an interactive committee of Center scientists, administrators and external advisors. Our mission is to maintain the Center's excellence through supporting projects with high potential for product development and maturation into independent research programs.