Development Research Plan

发展研究计划

• 批准号: 8234057
• 负责人: ASHLEE V. MOSES
• 金额: $ 62.39万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8234057
• 关键词: Address; Administrator; Biological; Bioterrorism; Categories; Communication; Complement; Defect; Development; Diagnostic; Electronics; Emerging Communicable Diseases; Emerging Technologies; Funding; Genetic; Goals; Growth; Immune system; Lead; Measures; Mission; National Institute of Allergy and Infectious Disease; Natural Immunity; Oregon; Pacific Northwest; Pilot Projects; Policies; Research; Research Personnel; Research Project Grants; Risk; Scientist; System; Systems Biology; Talents; Technology; Translational Research; Washington; adaptive immunity; age related; base; biodefense; combat; flexibility; innovation; novel; pathogen; product development; programs; research and development; therapeutic vaccine; vaccine development

The goal of the Developmental Research Plan is to identify and support pilot projects that complement the strategic mission of the PNWRCE. The PNWRCE will advance strategies to combat NIAID Category A-C agents via the development of two themes: "Identification of age-related defects in the immune system to facilitate the development of vaccines and supplemental therapies" and "The use of systems biology and systems genetics approaches to define pathogen-host interactions and mechanisms of innate and adaptive immunity." Applications will be encouraged from scientists within the RCE and from eligible regional scientists wishing to move into biodefense/EID research. Thus, we will leverage the pilot project mechanism to expand the scope and excellence of biodefense/EID research in the PNW region and develop a cutting edge research portfolio to sustain and enrich Center's activities. Three Specific Aims are proposed to achieve these goals: (1) To solicit, identify and support developmental research projects ("pilot" projects) that expand the scope and range of investigators within the Pacific Northwest (PNW) region and take advantage of novel ideas and emerging technologies relevant to PNWRCE themes. (2) To support the growth of successful pilot projects into independent research grants that will lead to development of products (vaccines, therapeutics or diagnostics) against NIAID A-C pathogens or key advances in biodefense/EID research. (3) To create, through the pilot project mechanism, a platform of emergent talents and technologies that could enhance or replace existing research projects, thereby creating flexibility for the Center to prioritize and advance in the most promising research directions. We will use electronic communication systems in association with established translational research initiatives in Oregon (OCTRI) and Washington (CTSA) to solicit applications from a broad talent base of eligible scientists. In accordance with NIAID policies, we will select, fund and manage successful applications via an interactive committee of Center scientists, administrators and external advisors. Our mission is to maintain the Center's excellence through supporting projects with high potential for product development and maturation into independent research programs.

发展研究计划的目的是识别和支持与之补充的试点项目 PNWRCE的战略任务。 PNWRCE将提出与NIAID类别a-c对抗的策略 通过开发两个主题的代理：“免疫系统中与年龄相关的缺陷的识别 促进疫苗和补充疗法的开发”和“系统生物学的使用和 系统遗传学方法来定义病原体宿主相互作用以及先天和适应性的机制 免疫力。 希望进入Biodefense/EID研究的科学家。因此，我们将利用试点项目机制 扩大PNW地区生物浮雕/开斋节研究的范围和卓越，并开发削减 边缘研究组合维持和丰富中心的活动。提出了三个具体目标 实现这些目标：（1）征求，识别和支持发展研究项目（“试点”项目） 扩大西北太平洋地区（PNW）地区的调查人员的范围和范围并利用优势 与PNWRCE主题相关的新颖思想和新兴技术。 （2）支持 成功的飞行员项目进入独立的研究补助金，这将导致产品开发 （疫苗，治疗剂或诊断）针对NIAID A-C病原体或Biodefense/EID的关键进展 研究。 （3）通过试点项目机制创建一个新兴才能的平台， 可以增强或取代现有研究项目的技术，从而为 沿最有希望的研究方向进行优先级和进步的中心。我们将使用电子 与俄勒冈州既定的转化研究计划（OCTRI）结合的通信系统 华盛顿（CTSA）征求合格科学家的广泛人才基础的申请。根据 通过NIAID政策，我们将通过一个交互式委员会选择，资助和管理成功的申请 中心科学家，管理员和外部顾问。我们的使命是保持中心的卓越性 通过支持具有很高潜力的产品开发和成熟到独立的项目 研究计划。