Genetics of Polygenic Obesity

多基因肥胖的遗传学

• 批准号: G0600331/1
• 负责人: Philippe Froguel
• 金额: $ 158.62万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600331%2F1
• 关键词: Genetics; Polygenic; Obesity

In the UK obesity (defined by a Body Mass Index 30kg/m2) is nearing epidemic proportions, with estimates of 1/3 of the population being affected within only a few years. Obesity predisposes to type 2 diabetes, coronary artery disease, osteoarthritis and some cancers leading to a significant reduction in life expectancy, especially in the young obese. Childhood obesity now affects 20-30% of children in the 5-10 years old age group. Although bad nutrition and sedentary lifestyle play a major role in this recent epidemics, severe and early onset forms of obesity both have a strong genetic basis and result from the cumulative effects of DNA variation in individuals living within an ?obesogenic? environment. In other words, genetically predisposed children are the first and most affected victims of our deleterious way of life. Identifying obesity and associated diabetes genes and risk bimarkers will provide vital information for the prevention and treatment of the condition, resulting in significant improvements in the quality of life and productivity in the UK population.

在英国，肥胖症（定义为体重指数30 kg/m2）已接近流行病的比例，估计有1/3的人口在短短几年内受到影响。肥胖易患2型糖尿病、冠状动脉疾病、骨关节炎和一些癌症，导致预期寿命显著缩短，特别是在年轻肥胖者中。儿童肥胖症现在影响到20-30%的5-10岁年龄组的儿童。虽然不良的营养和久坐不动的生活方式发挥了重要作用，在这最近的流行病，严重和早发性肥胖都有很强的遗传基础，并导致在个人生活的DNA变异的累积效应？肥胖的？环境换句话说，遗传倾向的儿童是我们有害生活方式的第一个和最受影响的受害者。确定肥胖和相关的糖尿病基因和风险双标记物将为预防和治疗这种疾病提供重要信息，从而显着改善英国人口的生活质量和生产力。