La Jolla Interdisciplinary Neuroscience Center Cores - Pro Core TSRI sat site

描述（由申请人提供）：这项机构间资助的总体目标是通过允许访问以前被拒绝或几乎无法访问的科学核心，并通过创建新的核心来促进最先进的技术，促进拉霍亚机构神经科学家之间的新的跨学科合作。为了实现这一目标，我们选择了现有最好的核心设施，并选择了顶级科学家在拉霍亚托里松梅萨支持神经科学家的机构中运行新的核心，这些机构包括伯纳姆医学研究所（BIMR）、索尔克研究所、斯克里普斯研究所（TSRI）和加州大学圣地亚哥分校（UCSD）。这些机构共享全国排名最高的神经科学研究生课程之一，并为这些核心投入了相当多的机构资金。这项工作的目的是开发新的治疗神经系统疾病的方法。具体目标包括：1。获得拉霍亚神经科学家的核心支持，使系统神经生物学的合作研究成为可能。本学科核心的例子有行为测试、电生理学、神经病理学、干细胞、生物信息学/系统生物学、病毒载体/siRNA和细胞成像/组织学。2. 为神经科学家提供核心支持，使合作发展神经生物学研究成为可能。本学科核心的例子有电生理学、细胞/分子成像、干细胞、蛋白质组学和病毒载体sirna文库。为神经科学家研究神经退行性疾病和开发神经保护疗法获得核心支持。该学科的核心包括蛋白质组学、结构生物学-晶体学、高通量细胞分析、化学文库筛选、行为测试、基因分析/cDNA微阵列、生物信息学、神经病理学、病毒载体- siRNA和干细胞。获得干细胞和再生医学领域神经科学家的核心支持。在这一领域需要协作工作的核心包括干细胞、蛋白质组学、基因分析/cDNA微阵列、生物信息学、神经病理学、电生理学、高通量细胞分析、化学筛选和行为测试。

DESCRIPTION (provided by applicant): The overall goal of this inter-institutional grant Is to foster new interdisciplinary collaborations among neuroscientists in La Jolla institutions by allowing access to scientific cores to which they were previously denied or had little access, and by creating new cores to promote state-of-the-art technology. To accomplish this goal, we have chosen among the very best existing core facilities, and have chosen top scientists to run new cores at the institutions supporting neuroscientists on the La Jolla Torrey Pines Mesa, composed of the Burnham Institute for Medical Research (BIMR), The Salk Institute, The Scripps Research Institute (TSRI), and the University of California, San Diego (UCSD). These institutions share one of the top-rated neuro- science graduate programs in the country and have committed considerable institutional funds towards these cores. This work is aimed at developing new treatments for neurological disorders. Specific Aims include: 1. To obtain Core support for Neuroscientists in La Jolla to enable collaborative research in Systems Neurobiology. Examples of Cores for this discipline are Behavioral testing, Electrophysiology, Neuropathology, Stem Cells, Bioinformatics/Systems Biology, Viral Vectors/siRNA, and Cell Imaging/Histology. 2. To obtain Core support for Neuroscientists to enable collaborative Developmental Neurobiology research. Examples of Cores for this discipline are Electrophysiology, Cell/Molecular Imaging, Stem Cells, Proteomics, and Viral Vectors-siRNA Libraries. 3. To obtain Core support for Neuroscientists studying Neurodegenerative Disorders and developing Neuroprotective Therapies. Cores to enable collaboration in this discipline include Proteomics, Structural Biology-crystallography, High-throughput Cell Analysis, Chemical Library Screening, Behavioral testing, Gene Analysis/cDNA Microarrays, Bioinformatics, Neuropathology, Viral Vectors- siRNA, and Stem Cells. 4. To obtain Core support for Neuroscientists working the area of Stem Cells and Regenerative Medicine. Cores needed for collaborative work in this area include Stem Cells, Proteomics, Gene Analysis/cDNA Microarrays, Bioinformatics, Neuropathology, Electrophysiology, High-throughput Cell Analysis Chemical Screening, and Behavioral testing.