IDENTIFICATION OF PHOSPHORYLATION SITES ON GLUTAMATE RECEPTOR MGLUR5

谷氨酸受体 MGLUR5 磷酸化位点的鉴定

• 批准号: 7954097
• 负责人: PAUL GREENGARD
• 金额: $ 0.12万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954097
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Funding; GRM5 gene; Glutamate Receptor; Grant; Institution; Mass Spectrum Analysis; Metabotropic Glutamate Receptors; Phosphorylation Site; Research; Research Personnel; Resources; Role; Site; Source; United States National Institutes of Health; macromolecule; mutant; novel; receptor function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. we are using hypothesis-driven mass spectrometry to identify novel phosphorylation sites on the metabotropic glutamate receptor, mGluR5. Mutants of the specific sites of phopshorylation will be constructed to obtain information about the roles of these sites on the function of the receptor.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们正在使用假设驱动的质谱法来鉴定代谢型谷氨酸受体mGluR 5上的新磷酸化位点。将构建磷酸化的特定位点的突变体，以获得关于这些位点对受体功能的作用的信息。