MECHANISMS FOR SELECTIVE REGULATION OF GAMMA-SECRETASE (AG09464-21A1 PROJ 2

选择性调节 γ 分泌酶的机制 (AG09464-21A1 项目 2

• 批准号: 8735057
• 负责人: PAUL GREENGARD
• 金额: $ 57.67万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735057
• 关键词: Adverse effects; Affect; Aging; Alzheimer' s Disease; Amyloid; Attenuated; Behavioral Assay; Binding; Binding Proteins; Biochemical; CSNK1A1 gene; Complex; Data; Development; Enzymes; Funding; Goals; Imatinib; In Vitro; Kinetics; Knock-out; Knockout Mice; Lipids; Mediating; Membrane Microdomains; Methods; Molecular; Molecular Conformation; Mus; Mutation; Names; Pathology; Peptide Hydrolases; Phosphorylation; Phosphorylation Site; Phosphotransferases; Post-Translational Protein Processing; Principal Investigator; Process; Production; Proteins; Regulation; Reporting; Role; Site; Specificity; Substrate Interaction; Substrate Specificity; System; Testing; Therapeutic; Tissues; Transgenic Mice; Ubiquitination; Vertebral column; Work; analog; base; gamma secretase; in vitro Assay; in vivo; mimetics; mouse model; neurotoxic; notch protein; novel; novel therapeutics; protein transport; secretase; therapeutic target; trafficking