Investigating FGF ERK MAP kinase signalling in vertebrate skeletal muscle differentiation

研究脊椎动物骨骼肌分化中的 FGF ERK MAP 激酶信号传导

• 批准号: G0600757/1
• 负责人: Andrea Munsterberg
• 金额: $ 39.28万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0600757%2F1
• 关键词: Investigating; FGF; ERK; MAP; kinase

All vertebrates, including human, contain many different cells with specialized functions. We want to understand how these different cell types arise from a single cell, the fertilized egg, during embryonic development.We know that cells in an embryo are told what to do by so-called signalling molecules. Many of these signals have been discovered in model organisms, and it is clear that the same signals are important to control human development. Interestingly, one specific signal can cause many different cellular responses. We think that it will be important to understand the mechanisms behind this, so that we might be able to control the differentiation of cells in culture.We will investigate how fibroblast growth factor (FGF) signals control the growth and differentiation of skeletal muscle cells during chick embryo development. This will help to identify the components required to make healthy skeletal muscle and should help to understand the mechanisms used during muscle regeneration and repair. We hope that in future the knowledge gained from our research will help to develop new therapies for people with muscle wasting, which happens because of long-term illness or old age.

所有脊椎动物，包括人类，都含有许多具有专门功能的不同细胞。我们想知道这些不同类型的细胞是如何在胚胎发育过程中从一个细胞（受精卵）中产生的，我们知道胚胎中的细胞是由所谓的信号分子告诉它们该做什么的。这些信号中的许多已经在模式生物中被发现，很明显，同样的信号对控制人类发育也很重要。有趣的是，一个特定的信号可以引起许多不同的细胞反应。我们认为，这将是重要的，以了解其背后的机制，使我们能够控制细胞的分化在culture.We将探讨成纤维细胞生长因子（FGF）信号如何控制骨骼肌细胞在鸡胚发育的生长和分化。这将有助于确定健康骨骼肌所需的成分，并有助于了解肌肉再生和修复过程中使用的机制。我们希望将来从我们的研究中获得的知识将有助于为由于长期疾病或老年而发生肌肉萎缩的人开发新的疗法。