Training in Cell Signaling and Lung Pathobiology

描述(由申请人提供)： 美国国立卫生研究院已经确定了在肺病理生物学的各个领域进行进一步研究的必要性，包括肺高压、急性肺损伤以及内皮细胞异质性对这些疾病的贡献。这些临床问题是多因素的，表明对潜在机制的更深入理解的发展将需要一支具有新的跨学科方法的研究人员队伍。然而，NIH资助的机构博士后培训项目的数量相对较少，特别是在由6个州组成的东南部地区，这些项目专门寻求为肺部奖学金和博士后培训项目提供高素质的博士后学生。我们的应用程序通过在该地区为计划从事细胞信号和肺部生物学职业的博士前学生提供最先进的学术课程来解决这一空白。这一培训计划的基础设施由南阿拉巴马大学医学院肺生物学中心提供，这是基础医学博士课程的跨学科核心课程，以及资金充足和国家认可的培训教师，他们带来了广泛的研究和培训专业知识。总体而言，这些教师将能够在细胞信号和肺部病理生物学之间的接口上提供出色的博士前培训。该培训计划将在项目第一年为4名博士前学生提供职位，并在随后的每一年为6名学生提供职位，并提供最短两年、最长三年的支持。除了要求以肺部生物学、肺部病理生理学和信号机制为重点的正式学术课程外，学员还将参加由肺生物学中心组织的系列研讨会和正在进行的研究论坛。拟议的培训计划将为博士前学生提供一个充满活力的学术研究环境。我们的目标是为肺部研究界提供丰富的资源，为竞争激烈的博士后职位提供训练有素的候选人。

DESCRIPTION (provided by applicant): NIH has identified the need for additional research in various areas of lung pathobiology, including pulmonary hypertension, acute lung injury and the contribution of endothelial cell heterogeneity to these diseases. These clinical problems are multifactorial, suggesting that the development of more in-depth understanding of the underlying mechanisms will require a workforce of investigators with new interdisciplinary approaches. However, the number of NIH-funded institutional predoctoral training programs that specifically seeks to supply pulmonary fellowship and postdoctoral training programs with highly qualified doctoral students is relatively few, particularly in the 6-state Southeast Region. Our application addresses this void by providing a state-of-the-art academic program in the region for predoctoral students planning a career in cell signaling and lung biology. The infrastructure for this training program is provided by the Center for Lung Biology at the University of South Alabama College of Medicine, an interdisciplinary core curriculum in Basic Medical Sciences Ph.D. program, and a well-funded and nationally-recognized training faculty who bring a breadth of research and training expertise. Collectively, these faculty will be able to provide outstanding predoctoral training at the interface between cell signaling and lung pathobiology. The training program will provide positions for 4 predoctoral students in the first year of the program and 6 students in each subsequent year, and supported for a minimum of two and a maximum of three years. In addition to the requirement for formal academic coursework focusing on lung biology, lung pathophysiology, and signaling mechanisms, trainees will participate the seminar series and research-in-progress forums organized by the Center for Lung Biology. The proposed training program will provide a vibrant academic research environment for predoctoral students. Our goal is to provide the pulmonary research community with a rich resource of well-trained candidates for competitive postdoctoral positions.