NIAMS: CORT (Psoriasis Center of Research Translation)

描述（由申请人提供）：位于大学医院病例医学中心的银屑病研究翻译中心将整合强大的银屑病和皮肤病研究基地，并拥有大量现有的银屑病患者队列。来自新的大学医院Murdough家庭银屑病中心的500万美元将进一步提高临床转诊网络的能力和地理位置，并与来自Case医学院的200万美元用于银屑病招募相结合，这些资源构成了对CORT的实质性机构承诺。皮肤病研究中心的皮肤生物学基础设施和经验将加速银屑病CORT的进步，使银屑病患者受益。设想的转化项目将测试基于新机制发现的银屑病创新治疗干预。它们还使用来自患者和动物模型的生物样品提供新的发病信息。每个项目都将产生改变银屑病患者治疗的治疗方式。项目1是一项新型光动力疗法（PDT）I期机制、安全性和初步疗效研究，该研究还开发了一种实时患者优化治疗设备。项目2是确定S100蛋白在银屑病发病机制中的新作用的基础研究，包括S100和巨噬细胞在异种移植物上银屑病皮肤中相互作用的原理验证测试。项目3利用一种新的银屑病样皮炎转基因小鼠模型来研究VEGF、S100 A8/9和血管变化在加重银屑病中的潜在作用。项目4探讨了银屑病患者心血管风险较高的新临床发现是否与S100 A8/9过表达有关，并讨论了针对S100血清水平的积极银屑病治疗是否会改善心血管风险。这些研究将得到两个以项目为重点的科学核心（A）统计学和B）系统生物学以及一个行政核心的支持。一个由男性和女性患者以及父母（其中一些人也是著名的科学家）代表的咨询委员会将监督CORT和P&F审查。因此，CORT将汇集来自不同部门和学科的翻译医生科学家，护士，社区临床医生，俗人和基础科学家的多学科团队，将该机构的智力和科学资源应用于银屑病患者的新疗法。

DESCRIPTION (provided by applicant): A Center of Research Translation in Psoriasis based at University Hospitals Case Medical Center will integrate a strong psoriasis and skin disease research base with a large existing cohort of psoriasis patients. $5M from the new University Hospitals Murdough Family Center for Psoriasis will further increase the capabilities and geography of the clinical referral network, and in combination with $2M from Case School of Medicine for recruitment in psoriasis, these resources comprise a substantial institutional commitment to the CORT. The Skin Diseases Research Center's cutaneous biology infrastructure and experience will accelerate the Case Psoriasis CORT's advances for psoriasis patient benefit. The translational projects envisioned will test innovative therapeutic interventions in psoriasis that are based upon new mechanistic findings. They also provide new pathogenetic information using biologic samples from patients and animal models. It is intended that each Project will generate therapeutic modalities that change the treatment of psoriasis patients. Project 1 is a novel photodynamic therapy (PDT) Phase I mechanistic, safety, and preliminary efficacy study which also develops a real-time patient-optimized therapy device. Project 2 is a basic study that determines novel roles for S100 proteins in the pathogenesis of psoriasis, including proof-of-principle testing of S100 and macrophage interplay in psoriasis skin on xenogenic transplants. Project 3 takes advantage of a novel transgenic mouse model of psoriasiform dermatitis to examine the potential role of VEGF, S100 A8/9 and vascular changes exacerbating psoriasis. Project 4 explores whether the new clinical finding that psoriasis patients are at higher cardiovascular risk is related to S100 A8/9 overexpression and addresses if aggressive psoriasis treatment directed at S100 serum levels improves cardiovascular risk. The studies will be supported by two project-focused scientific Cores in A) Statistics and B) Systems Biology, and by an Administrative Core. An Advisory Board with representation by both male and female patients, as well as parents, some of whom are also renowned scientists, will oversee the CORT and the P&F review. The CORT will thus bring a multidisciplinary team of translational physician scientists, nurses, community clinicians, laity, and basic scientists from different departments and disciplines together to apply the intellectual and scientific resources of the institution to new therapies for psoriasis patients.