Developmental Research Program

认识到发展研究基金是SPORE的一个组成部分，我们承诺每 这些年的努力。这在UMCCC前列腺预算中占很大比例 SPORE并反映了该计划对创新发展的持续承诺 前列腺癌的转化研究。发展研究计划的重点是提供 研究人员能够生成数据，这些数据将成为R 01赠款申请的初步数据 或同等的提议。鼓励前列腺癌领域以外的研究人员申请 通过校园范围内的公告以及通过与SPORE的个人互动， investigators.我们为试点项目制定了一个逐步的提案征集和审查流程， NIH型PHS 398格式，经过简化，可快速周转研究提案， 认识到这些项目可能没有多少初步数据。研究人员可以申请试点项目 赠款（每年40 000 - 50 000美元）或种子赠款（每年5 000 - 10 000美元）。自1995年以来， 52个试点项目和61个种子赠款，总投资为250万美元。这导致了超过20美元的 100万美元的后续赠款和101手稿。Maha Hussain博士和Mark Day博士担任联合... 发展研究计划的主管。侯赛因博士是内科教授， 泌尿外科，并在国内和国际上认可她的科学临床研究专业知识， 生殖肿瘤领域，特别是前列腺癌和膀胱癌。她作为“临床”专家 研究开发项目的。Mark'Day博士是泌尿学教授， 广泛应用于前列腺细胞生物学领域。他担任研究的“基础科学”导师 发展计划。Day博士是泌尿外科培训补助金的PI，并作为导师参加 癌症生物学培训补助金。Hussain博士和Day博士与每个项目研究员会面两次， 中求进工作总项目调查人员还参加每月的SPORE会议和年度务虚会。

Recognizing that developmental research funds are an integral part of the SPORE, we commit $175,000 per year to these endeavors. This represents a significant percent in the budget of the UMCCC Prostate SPORE and reflects the continued commitment of this program to the development of innovative translational research in prostate cancer. The focus of the Developmental Research Program is to provide investigators the ability to generate data that would become the preliminary data for an R01 grant application or an equivalent proposal. Investigators from outside the field of prostate cancer are encouraged to apply through campus wide announcements as well as through personal interactions with the SPORE investigators. We developed a stepwise proposal solicitation and review process for pilot projects utilizing a NIH-type PHS 398 format that has been streamlined for rapid turn around of research proposals and which recognizes that these projects may have little preliminary data. Investigators may apply for pilot project grants ($40,000 - $50,000 per year) or seed grants ($5,000 - $10,000 per year). Since 1995 we have funded 52 pilot projects and 61 seed grants with a total investment of $2.5 million. This has resulted in over $20 million in subsequent grants and 101 manuscripts. Dr. Maha Hussain and Dr. Mark Day serve as Co- Directors for the Developmental Research Program. Dr. Hussain is a Professor of Internal Medicine and Urology, and is nationally and internationally recognized for her scientific clinical research expertise in the area of genitourinary-oncology, particularly prostate and bladder cancers. She serves as the "clinical" expert for the Research Development Program. Dr. Mark'Day is a Professor of Urology and has published extensively in the area of prostate cell biology. He serves as the "basic science" mentor of the Research Development Program. Dr. Day is the PI of the Urology Training Grant and participates as a mentor in the Cancer Biology Training Grant. Drs. Hussain and Day meet twice with each project investigator to review progress. Project investigators also take part in the monthly SPORE meetings and annual retreat.