fMRI of choice and Response Impulsivity in CD

CD 中选择的功能磁共振成像和反应冲动

• 批准号: 7797225
• 负责人: Marc N Potenza
• 金额: $ 11.44万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797225
• 关键词: Alcohol or Other Drugs use; Anterior; Binding; Brain; Clinical; Cocaine; Cocaine Dependence; Color; Complex; Corpus striatum structure; Data; Development; Disease; Dopamine; Dorsal; Drug Addiction; Education; Etiology; Event; Exposure to; Functional Magnetic Resonance Imaging; Gender; Human; Impulsivity; Incentives; Individual; Individual Differences; Investigation; Link; Literature; Measures; Methylphenidate; Neurobiology; Neurocognitive; Outcome Study; Patient Self-Report; Performance; Pharmaceutical Preparations; Phenotype; Positron-Emission Tomography; Prevention; Process; Public Health; Publishing; Research; Rewards; Sampling; Self Administration; Signal Transduction; Task Performances; Treatment outcome; Ventral Striatum; Wit; addiction; base; behavior measurement; cingulate cortex; clinically relevant; cocaine use; cognitive control; improved; prevent; receptor function; relating to nervous system; response; reward processing; treatment strategy

Cocaine addiction respresents a devastating human condition. The complexities of drug addictions have slowed the development of effective prevention and treatment strategies. Impulsivity is an important construct that has been linked to the vulnerability to addictive processes. Additionally, the exposure to addictive drugs has been associated with increased impulsivity. However, the relationhip between impulsivity and addiction appears complex and pooriy understood, partially because of the complexity of impulsivity. Impulsivity has been found to factor into two main domains (choice and response) that appear associated with different aspects of drug addiction. However, the neurobiological substrates of these forms of impulsivity in drug addiction are not well understood. We propose investigating in individuals with and without cocaine dependence the neural substrates of choice and response impulsivity using functional magnetic resonance imaging (fMRI), with specific paradigms assessing each domain. Additionally, we will collect fMRI data to assess cognitive control and reward processing in the same subjects. Subjects in this project will also participate in project 2 assessing striatal dopamine D2/D3 receptor function and in the Clinical and Educational Core in which a comprehensive battery of clinical and neurcognitive measures will be obtained. This information will include information on stimulant influences on choice and response impulsivity and (amongst the cocaine dependent subjects) cocaine self administration. By integrating information across studies, a more complete understanding of the brain function underiying impulsivity as it relates to cocaine addiction will be achieved. Such information has significant potential to inform investigations into more effective prevention and treatment strategies for cocaine addiction.

可卡因成瘾代表了一种毁灭性的人类状况。吸毒成瘾的复杂性减缓了有效预防和治疗战略的发展。冲动是一个重要的结构，它与上瘾过程的脆弱性有关。此外，接触令人上瘾的药物与冲动增加有关。然而，冲动和上瘾之间的关系似乎很复杂，也很难理解，部分原因是冲动的复杂性。 冲动被发现存在于两个主要领域(选择和反应)，这两个领域似乎与药物成瘾的不同方面有关。然而，药物成瘾中这些形式的冲动的神经生物学基础还没有被很好地理解。我们建议使用功能磁共振成像(FMRI)研究有可卡因依赖和没有可卡因依赖的个体的神经选择底物和反应冲动，并使用特定的范式评估每个领域。此外，我们还将 收集fMRI数据以评估同一受试者的认知控制和奖励处理。该项目的受试者还将参与评估纹状体多巴胺D2/D3受体功能的项目2以及临床和教育核心项目，在该项目中将获得一系列全面的临床和神经认知测量方法。这些信息将包括有关兴奋剂对选择和反应的影响的信息 冲动和(在可卡因依赖受试者中)可卡因自我给药。通过整合研究中的信息，将实现对冲动与可卡因成瘾相关的大脑功能的更全面的了解。这类信息对于更有效地预防和治疗可卡因成瘾战略的调查具有很大潜力。