fMRI of choice and Response Impulsivity in CD

可卡因成瘾是一种毁灭性的人类疾病。吸毒成瘾的复杂性减缓了制定有效预防和治疗战略的速度。冲动性是一个重要的结构，它与成瘾过程的脆弱性有关。此外，接触成瘾药物与冲动性增加有关。然而，冲动性和成瘾之间的关系似乎很复杂，而且人们对它的理解也很少，部分原因是冲动性的复杂性。 冲动性被认为是两个主要领域（选择和反应）的因素，这两个领域似乎与药物成瘾的不同方面有关。然而，这些形式的冲动在药物成瘾的神经生物学基板没有很好地理解。我们建议调查在个人与可卡因依赖和不依赖的神经基板的选择和反应冲动使用功能性磁共振成像（fMRI），与特定的范例评估每个域。此外，我们将 收集功能磁共振成像数据，以评估同一受试者的认知控制和奖励处理。本项目中的受试者还将参加项目2，评估纹状体多巴胺D2/D3受体功能，并参加临床和教育核心，其中将获得一系列全面的临床和神经认知测量。这些信息将包括刺激物对选择和反应的影响 冲动和（可卡因依赖受试者中）可卡因自我给药。通过整合跨研究的信息，将实现对冲动性背后的大脑功能的更完整的理解，因为它与可卡因成瘾有关。这类信息具有很大的潜力，可为调查提供信息，以更有效地预防和治疗可卡因成瘾。

Cocaine addiction respresents a devastating human condition. The complexities of drug addictions have slowed the development of effective prevention and treatment strategies. Impulsivity is an important construct that has been linked to the vulnerability to addictive processes. Additionally, the exposure to addictive drugs has been associated with increased impulsivity. However, the relationhip between impulsivity and addiction appears complex and pooriy understood, partially because of the complexity of impulsivity. Impulsivity has been found to factor into two main domains (choice and response) that appear associated with different aspects of drug addiction. However, the neurobiological substrates of these forms of impulsivity in drug addiction are not well understood. We propose investigating in individuals with and without cocaine dependence the neural substrates of choice and response impulsivity using functional magnetic resonance imaging (fMRI), with specific paradigms assessing each domain. Additionally, we will collect fMRI data to assess cognitive control and reward processing in the same subjects. Subjects in this project will also participate in project 2 assessing striatal dopamine D2/D3 receptor function and in the Clinical and Educational Core in which a comprehensive battery of clinical and neurcognitive measures will be obtained. This information will include information on stimulant influences on choice and response impulsivity and (amongst the cocaine dependent subjects) cocaine self administration. By integrating information across studies, a more complete understanding of the brain function underiying impulsivity as it relates to cocaine addiction will be achieved. Such information has significant potential to inform investigations into more effective prevention and treatment strategies for cocaine addiction.