Dietary Inorganic Phosphate as a Target for Nutritional intervention in Cancer
膳食无机磷酸盐作为癌症营养干预的目标
基本信息
- 批准号:7896743
- 负责人:
- 金额:$ 7.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-20 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:Action PotentialsAdenocarcinomaAffectAmericanAreaBe++ elementBehaviorBenefits and RisksBerylliumBiological AssayCalciumCancer EtiologyCell ProliferationCell divisionCell modelCell physiologyCellsCessation of lifeChemopreventionComplexDevelopmentDietDiet and NutritionDietary ComponentDietary FactorsDietary InterventionDietary intakeDiseaseDisease ProgressionElementsEndocrineEnergy MetabolismEnvironmental Risk FactorEpidemiologyEventFatty acid glycerol estersFood AdditivesGene ExpressionGenesGeneticGenetic TranscriptionGenitourinary systemGrowthHealthHealth BenefitHistologyHyperplasiaImmunohistochemistryIn VitroIncidenceIndividualIntakeInterventionLife StyleLong-Term EffectsMalignant NeoplasmsMalignant neoplasm of prostateMeasuresMetastatic CarcinomaModelingMolecularMolecular ProfilingMusNeoplasm MetastasisNeoplasmsNutritionalParathyroid HormonesPlayPost-Translational Protein ProcessingPredisposing FactorPrevalenceProcessPropertyProstatePublishingReducing dietRelative (related person)ResearchResearch PersonnelRoleSerumSignal Transduction PathwaySignaling MoleculeSignaling Pathway GeneStressTestingTherapeuticTissuesTransgenic OrganismsVitamin DWeightbasecancer cellcancer initiationcancer preventioncell behaviorcell typecombinatorialdisorder preventionenergy balancefeedingfunctional genomicshuman PTH proteinhuman migrationin vivoinorganic phosphatelifestyle factorsmenmouse modelneglectnovelosteopontinpressureresponsetherapeutic targettumor progressiontumorigenesis
项目摘要
DESCRIPTION (provided by applicant):
It is becoming increasingly apparent that diet can have profound effects on functional genomics. However, this area of research has only begun to be exploited for therapeutic benefit. Understanding the role of individual dietary components in promoting health or disease will open new opportunities to intervene in both disease prevention and treatment. Cancer of the prostate is known to be influenced by life style factors such as diet. Our preliminary in vitro results suggest that the concentration of inorganic phosphate that prostate cells are exposed to is an important predisposing factor in the growth potential of cells and alters the expression of transformation and metastasis associated genes such as osteopontin and Egr-1. Inorganic phosphate is also a critical component of cellular energy which raises a number of questions regarding the events associated with excess and/or limited cellular phosphate: Does the amount of available serum phosphate alter the growth properties of the cell in vivo? Does the amount of available phosphate alter the response of the cell in the presence of a transformational pressure? Surprisingly, little is known about the potential positive or negative effects of altered serum levels of inorganic phosphate on cell and tissue behavior related to health and disease. As the amount of phosphate in the American diet continues to rise beyond levels already considered high by the FDA it will be important to understand the long-term health benefits and risks associated with this common dietary element. This application will test the hypothesis that: a reduced inorganic phosphate diet reduces development and/or progression of prostate cancer. To test this hypothesis we will utilize an existing and well defined mouse model, the transgenic adenocarcinoma of the mouse prostate (TRAMP). Specifically, results from this application will determine whether a diet low in inorganic phosphate reduces development and/or progression of prostate cancer in the TRAMP model, relative to a diet high in phosphate. The extent of cancer development and progression will be measured by genitourinary tract weight and graded histology. Based on preliminary results, altered levels of serum inorganic phosphate might influence prostate function by two possible mechanisms; 1) directly affecting cell function by altering the expression of specific genes such as osteopontin and Egr-1, which we will measure by immunohistochemistry and molecular characterization of the neoplasia and/or 2) altering the levels of one or more circulating factors such as vitamin D or osteopontin which we will measure in the serum.
描述(由申请人提供):
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GEORGE R. BECK其他文献
GEORGE R. BECK的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GEORGE R. BECK', 18)}}的其他基金
Novel strategies to target lung cancer metastasis to bone
针对肺癌骨转移的新策略
- 批准号:
10646351 - 财政年份:2022
- 资助金额:
$ 7.75万 - 项目类别:
Novel strategies to target lung cancer metastasis to bone
针对肺癌骨转移的新策略
- 批准号:
10513138 - 财政年份:2022
- 资助金额:
$ 7.75万 - 项目类别:
ShEEP Request For A Pre-Clinical In-Vivo X-Ray Micro Computed-Tomography Scanner
ShEEP 请求临床前体内 X 射线微型计算机断层扫描仪
- 批准号:
10178581 - 财政年份:2020
- 资助金额:
$ 7.75万 - 项目类别:
Bio-active Nanoparticles and the stimulation of autophagy for improved bone mass
生物活性纳米颗粒和刺激自噬以改善骨量
- 批准号:
9280823 - 财政年份:2014
- 资助金额:
$ 7.75万 - 项目类别:
Bio-active Nanoparticles and the stimulation of autophagy for improved bone mass
生物活性纳米颗粒和刺激自噬以改善骨量
- 批准号:
8974367 - 财政年份:2014
- 资助金额:
$ 7.75万 - 项目类别:
Bio-active Nanoparticles and the stimulation of autophagy for improved bone mass
生物活性纳米颗粒和刺激自噬以改善骨量
- 批准号:
8634211 - 财政年份:2014
- 资助金额:
$ 7.75万 - 项目类别:
Contribution of Phosphate to Inflammatory Bone Loss
磷酸盐对炎性骨质流失的影响
- 批准号:
10588936 - 财政年份:2013
- 资助金额:
$ 7.75万 - 项目类别:
Inorganic phosphate regulated proliferation, transformation and tumorigenesis
无机磷酸盐调节增殖、转化和肿瘤发生
- 批准号:
8444660 - 财政年份:2010
- 资助金额:
$ 7.75万 - 项目类别:
Inorganic phosphate regulated proliferation, transformation and tumorigenesis
无机磷酸盐调节增殖、转化和肿瘤发生
- 批准号:
7889954 - 财政年份:2010
- 资助金额:
$ 7.75万 - 项目类别:
Inorganic phosphate regulated proliferation, transformation and tumorigenesis
无机磷酸盐调节增殖、转化和肿瘤发生
- 批准号:
8076343 - 财政年份:2010
- 资助金额:
$ 7.75万 - 项目类别:
相似国自然基金
大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
- 批准号:30840003
- 批准年份:2008
- 资助金额:12.0 万元
- 项目类别:专项基金项目
相似海外基金
Synergistic Radiosensitization of Hypoxic Pancreatic Adenocarcinoma using Gd-Texaphyrin Oxygen-Loaded Nanodroplets
使用 Gd-Texaphyrin 载氧纳米液滴对缺氧胰腺腺癌进行协同放射增敏
- 批准号:
478914 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Operating Grants
Expression mechanism of immune checkpoint molecules after carbon-ion radiotherapy in cervical adenocarcinoma specimens
宫颈腺癌碳离子放疗后免疫检查点分子的表达机制
- 批准号:
23K14913 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Study of fibrosis in pancreatic ductal adenocarcinoma (PDAC) and application of adipose-derived stromal/stem cells for PDAC treatment
胰腺导管腺癌(PDAC)纤维化的研究以及脂肪源性基质/干细胞在 PDAC 治疗中的应用
- 批准号:
23K15035 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
IRAK4 AS A NOVEL IMMUNOTHERAPEUTIC TARGET IN PANCREATIC DUCTAL ADENOCARCINOMA
IRAK4 作为胰腺导管腺癌的新型免疫治疗靶点
- 批准号:
10442874 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Therapeutic Targeting of NSD2 in Lung Adenocarcinoma
NSD2 在肺腺癌中的治疗靶向
- 批准号:
10657069 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Control mechanisms of lung adenocarcinoma by SGLT2 inhibitors for treating diabetes mellitus.
SGLT2抑制剂治疗糖尿病对肺腺癌的控制机制。
- 批准号:
23K08326 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Establishment of histological transformation model from lung small cell carcinoma from adenocarcinoma to explore the therapeutic strategies of small cell lung carcinoma.
建立肺小细胞癌腺癌组织学转化模型,探讨小细胞肺癌的治疗策略。
- 批准号:
23K14614 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of the mechanisms of tumor progression controlled by tumor-initiating cells and cancer-associated fibroblasts in pancreatic adenocarcinoma.
阐明胰腺腺癌中肿瘤起始细胞和癌症相关成纤维细胞控制的肿瘤进展机制。
- 批准号:
23K15075 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Molecular mechanisms for development of pulmonary invasive mucinous adenocarcinoma
肺浸润性粘液腺癌发生的分子机制
- 批准号:
23H02698 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Elucidating the Cellular Origins of lung adenocarcinoma
阐明肺腺癌的细胞起源
- 批准号:
10743611 - 财政年份:2023
- 资助金额:
$ 7.75万 - 项目类别: