Centre for Developmental and Biomedical Genetics

发育和生物医学遗传学中心

• 批准号: G0700091/1
• 负责人: Philip Ingham
• 金额: $ 305.09万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700091%2F1
• 关键词: Centre; Developmental; Biomedical; Genetics

Many human diseases involve interactions between various cell types, tissues and organ systems that cannot readily be reproduced in the tissue culture dish. The main goal of the Centre for Developmental and Biomedical Genetics is to use non-mammalian species to model human disease processes in a whole organism context. Our approach is based on discoveries made in the past two decades that have revealed that organisms as simple as a tropical fish, fruit fly or even a worm share many cellular functions and have many genes in common with humans. By manipulating these organisms’ versions of human disease associated genes, we can establish models for a variety of debilitating diseases and exploit these to discover new therapeutic agents. In addition, we can generate pathological conditions – such as the blockage of arteries – in these simple organisms and use these to discover novel genes that underlie the corresponding human pathology. Through these approaches we aim to expand our knowledge of the molecular basis of a range of human diseases, including cardiovascular, inflammatory and neurodegenerative, giving new insights into their causes and providing new leads for their diagnosis, management and cure.

许多人类疾病涉及各种细胞类型、组织和器官系统之间的相互作用，而这些细胞类型、组织和器官系统不容易在组织培养皿中复制。发育和生物医学遗传学中心的主要目标是利用非哺乳动物物种在整个生物体范围内模拟人类疾病过程。我们的方法是基于过去20年的发现，这些发现表明，像热带鱼、果蝇甚至蠕虫这样简单的生物具有许多细胞功能，并具有许多与人类相同的基因。通过操纵这些生物版本的人类疾病相关基因，我们可以为各种令人衰弱的疾病建立模型，并利用这些模型来发现新的治疗剂。此外，我们可以在这些简单的生物体中产生病理条件--例如动脉阻塞--并利用这些条件发现构成相应人类病理基础的新基因。通过这些方法，我们的目标是扩大我们对包括心血管疾病、炎症疾病和神经退行性疾病在内的一系列人类疾病的分子基础的了解，为其病因提供新的见解，并为其诊断、管理和治疗提供新的线索。