DPFS Resource request (University of Sheffield) A High-content high-throughput Screening Facility in an Academic Setting

DPFS 资源请求（谢菲尔德大学）学术环境中的高内容高通量筛选设施

• 批准号: G0801680/1
• 负责人: Philip Ingham
• 金额: $ 6.47万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0801680%2F1
• 关键词: DPFS; Resource; request; University; Sheffield

Thanks to the recent multi-national efforts to sequence the entire genomes of species as diverse as worms and humans, we now know that humans and lower organisms share remarkably similar sets of genes. This finding has transformed our understanding of human biology, through the realisation that many of the cellular and biochemical processes controlled by these genes in simple organisms also operate in ourselves. Most of our knowledge about the control of cells and organ systems has come from the study of a few so-called ?model organisms?, especially the fruit fly Drosophila melanogaster, and the tropical fish Danio rerio (commonly known as the zebrafish). Studies of such organisms have the potential to revolutionise our understanding, diagnosis and treatment of human disease, a premise that underpins the activities of the MRC Centre for Developmental and Biomedical Genetics. A key aim of the Centre is to encourage the rapid translation of our basic research findings into clinical application. This proposal will facilitate such translation by providing the means to screen for small molecules that can modulate pathogenic processes in model organisms. Such small molecules will provide powerful tools for probing the molecular basis of these processes and in some cases will provide leads for the developments of new drugs for their treatment.

由于最近多国努力对各种物种的整个基因组进行测序，就像蠕虫和人类一样，我们现在知道，人类和低等生物拥有非常相似的一组基因。这一发现改变了我们对人类生物学的理解，因为我们意识到，在简单生物体中，由这些基因控制的许多细胞和生化过程也在我们自己身上运作。我们关于细胞和器官系统控制的大部分知识都来自于对一些所谓的模式生物的研究，特别是果蝇黑腹果蝇和热带鱼Danio rerio(俗称斑马鱼)。对这类生物的研究有可能彻底改变我们对人类疾病的理解、诊断和治疗，这是MRC发育和生物医学遗传学中心活动的基础。该中心的一个主要目标是鼓励我们的基础研究成果迅速转化为临床应用。这项提议将通过提供手段来筛选可以在模式生物中调节致病过程的小分子，从而促进这种翻译。这种小分子将为探索这些过程的分子基础提供强大的工具，在某些情况下还将为开发治疗这些疾病的新药提供线索。