Identifying cell type specific biomarkers of recurrent oral squamous cell carcinoma and mapping cancer-stroma interactions using single cell biology and cell-to-cell communication networks

使用单细胞生物学和细胞间通讯网络识别复发性口腔鳞状细胞癌的细胞类型特异性生物标志物并绘制癌症-基质相互作用图谱

• 批准号: nhmrc : GNT1146323
• 负责人: Prof Alistair Forrest
• 金额: $ 88.05万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-cell-type-communication-networks/1348753
• 关键词: Identifying; cell; type; specific; biomarkers

Cancer is a major cause of death in Australia. Despite advances in our understanding of the mutations that occur and the sets of genes expressed in cancer we have a major gap in our understanding of what is happening within tumours. Using new single cell technology we will generate new molecular portraits of cancers that give us understanding of the sets of genes expressed on individual cancer cells, the normal cells within a tumour and how they interact with cancer cells to form a tumour.

癌症是澳大利亚的主要死因。尽管我们对癌症中发生的突变和表达的基因组的理解取得了进展，但我们对肿瘤内发生的事情的理解仍存在重大差距。使用新的单细胞技术，我们将产生新的癌症分子画像，使我们了解单个癌细胞上表达的基因组，肿瘤内的正常细胞以及它们如何与癌细胞相互作用形成肿瘤。