Identification of the conformation dependant targets of autoimmune disease linked variation in human regulatory T cells

人类调节性 T 细胞中自身免疫性疾病相关变异的构象依赖性靶标的鉴定

• 批准号: nhmrc : 1120543
• 负责人: Prof Alistair Forrest
• 金额: $ 68.43万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-conformation-dependant-t-cells/946561
• 关键词: Identification; conformation; dependant; targets; autoimmune

Specialised immune cells called regulatory T cells act as the policemen of the immune system, preventing the immune system attacking itself, but still fighting infections. If these cells do not work properly, autoimmune diseases such as type 1 diabetes or IBD can arise, because of immune attack on normal body tissue by mistake. In order to explain how this goes wrong we need to carefully identify all of the gene interactions in these cells including interactions over long distances in the DNA.

称为调节性 T 细胞的特殊免疫细胞充当免疫系统的警察，防止免疫系统攻击自身，但仍能抵抗感染。如果这些细胞不能正常工作，由于免疫系统错误地攻击正常身体组织，可能会出现 1 型糖尿病或 IBD 等自身免疫性疾病。为了解释这是如何出错的，我们需要仔细识别这些细胞中的所有基因相互作用，包括 DNA 中长距离的相互作用。