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Toll like receptors and chemokine receptors: 2 interconnected arms of the innate immune response.

Toll 样受体和趋化因子受体：先天免疫反应的两个相互关联的分支。

基本信息

批准号：
G0700120/1
负责人：
Gerard Graham
金额：
$ 72.03万
依托单位：
University of Glasgow
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=G0700120%2F1
关键词：
Toll like receptors chemokine interconnected

项目摘要

When we are infected by a virus, or a bacteria, or a parasite, we mount specialised responses called immune responses. At the start of this process, the first thing we have to be able to do is to register the fact that we have been infected. This is achieved using specialised molecules called Toll Like Receptors, which sense the infecting agents and start to initiate an immune response. We have a number of Toll Like Receptors which are specialised in recognising different types of invading organisms. One of the ways in which Toll Like Receptors initiate the immune response is by inducing the synthesis of a different class of molecules called chemokines which are essential in helping to get white blood cells to the infected sites. The white blood cells are important in helping to start the process of destruction of the invading organisms and this results in inflammation developing around the infected sites. Eventually we mount a full immune response to the invading organism and, all being well, this will ensure its removal from our body. We are interested in how the Toll Like Receptor and Chemokine families interact to coordinate our response to infection. Understanding this interaction is central to our understanding of our response to invading organisms and will provide invaluable data that may help us to improve our responses to such agents.

当我们被病毒、细菌或寄生虫感染时，我们会产生特殊的反应，称为免疫反应。在这个过程的开始，我们必须能够做的第一件事是登记我们已经被感染的事实。这是通过使用称为Toll样受体的专门分子来实现的，这些分子可以感知感染因子并开始启动免疫反应。我们有许多Toll样受体，专门识别不同类型的入侵生物。Toll样受体启动免疫反应的方式之一是诱导合成一种称为趋化因子的不同类型的分子，这些分子在帮助白色血细胞到达感染部位方面至关重要。白色血细胞在帮助开始破坏入侵生物体的过程中很重要，这导致感染部位周围的炎症发展。最终，我们对入侵的生物体产生了全面的免疫反应，一切顺利，这将确保它从我们的身体中清除。我们感兴趣的是Toll样受体和趋化因子家族如何相互作用，以协调我们对感染的反应。了解这种相互作用对于我们理解我们对入侵生物的反应至关重要，并将提供宝贵的数据，可以帮助我们改善对这些代理人的反应。