Regulation of the adaptive immune response by chemokine scavenging receptors

趋化因子清除受体调节适应性免疫反应

• 批准号: G0901113/1
• 负责人: Gerard Graham
• 金额: $ 221.27万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901113%2F1
• 关键词: Regulation; adaptive; immune; response; chemokine

When our bodies are invaded by foreign organisms such as bacteria or viruses, we mount what is called an immune response. This requires the careful orchestration of cell movement throughout the body, without which the immune response would not be properly developed. Much of the movement of the immune cells is regulated by specialised proteins which are called Chemokines. It is with these proteins that we work. We have identified molecules that can degrade some of the chemokines and therefore remove them from the area surrounding cells. We believe that this is important for the proper working of the immune system. The current proposal aims to study these molecules, which we call scavengers, in much more detail and to carefully examine their roles in helping the development of immune responses. The data we generate will therefore help us to understand the regulation of the immune response in much more detail and will have implications for our ability to therapeutically manipulate this process. In addition, sometimes chemokines can play deleterious roles and can be at the root cause of diseases such as arthritis and psoriasis. We believe that we might be able to use these scavenger molecules in disease contexts to switch off inflammation. We will therefore try to develop anti-inflammatory agents based on our knowledge of these scavenger molecules and will partner with a large Pharmaceutical company to help develop their therapeutic potential.

当我们的身体被细菌或病毒等外来生物入侵时，我们会产生所谓的免疫反应。这需要仔细协调整个身体的细胞运动，否则免疫反应将无法正常发展。免疫细胞的大部分运动是由称为趋化因子的专门蛋白质调节的。我们就是用这些蛋白质工作的。我们已经鉴定出可以降解某些趋化因子的分子，从而将它们从细胞周围区域移除。我们认为这对免疫系统的正常工作很重要。目前的提案旨在更详细地研究这些我们称之为清道夫的分子，并仔细研究它们在帮助免疫反应发展中的作用。因此，我们生成的数据将帮助我们更详细地了解免疫反应的调节，并将对我们在治疗上操纵这一过程的能力产生影响。此外，有时趋化因子可以发挥有害的作用，可以是关节炎和牛皮癣等疾病的根本原因。我们相信，我们可能能够在疾病背景下使用这些清道夫分子来关闭炎症。因此，我们将尝试根据我们对这些清道夫分子的了解开发抗炎剂，并将与一家大型制药公司合作，帮助开发其治疗潜力。