CTSA INFRASTRUCTURE FOR AIDS RESEARCH

CTSA 艾滋病研究基础设施

• 批准号: 8173857
• 负责人: David D McPherson
• 金额: $ 20.83万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173857
• 关键词: Acquired Immunodeficiency Syndrome; Research; Research Infrastructure

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. The University of Texas Health Science Center at Houston (UTHSC-H) proposes to establish a Center for Clinical and Translational Sciences (CCTS) in the Texas Medical Center (TMC), Houston, Texas. Participating faculty and trainees in the CCTS will include those from the UTHSC-H component degree granting schools, including its School of Medicine, School of Public Health, Graduate School of Biomedical Sciences, School of Health Information Sciences, School of Nursing, Dental School and Institute of Molecular Medicine (IMM), as well as collaborating faculty/facilities from the UT M.D. Anderson Cancer Center (MDACC) and which also is located in the TMC. The academic "home" for the CCTS will be located in 11,422 sq ft of newly renovated and CCTS-designated space at the UTH Medical School which is physically joined to the Memorial Hermann Hospital (MHH) and serves as its partner and major teaching hospital. The CCTS "home" will administer all aspects of the CCTS and provide space and resources for faculty and trainees, along with expertise in study design, biostatistics, regulatory issues, ethics, and bioinformatics, and funding of Pilot and Feasibility Studies, provision of resources and protected time for clinical and translational faculty and trainees and interactions/collaborations with the various communites and industry. For Participant and Clinical Interactions Resources (PCIR), the CCTS will subsume the UTHSC-H General Clinical Research Center (GCRC) at MHH, the satellite UTHSC-H GCRC at Brownsville, Texas, and, in part, the MDACC Clinical and Translational Research Center to enhance research productivity and efficiency. In its Educational Component, the CCTS will subsume, in part, the current Center for Clinical Research and Evidence-Based Medicine, which has developed and currently provides formal classes, mentoring, and a Masters Degree in Clinical Research (MCR) at UTHSC-H, and an active NCRR K30 award at MDACC. Also proposed in the application is a novel T32 application offering combinations of Masters and PhD degrees in Community Health Sciences,'Biomedical Sciences and/or Biomedical Informatics, primarily for pre-doctoral students, and a K12 application for post-doctoral trainees and junior faculty. The CCTS also will subsume Core Translational Laboratories, including a Genotyping/Sequencing Corel a Biomarkers Core offering DNA Microarray, RT-PCR and Proteomics services , an Immune Monitoring Core, an MRI Imaging Core, and a Biobanking Core. A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and community representatives, will come together as an "engine for innovation" to bring forward and recommend the application of novel and emerging scientific information, methods and technologies to research into human health and diseases across specialties, disciplines and communities.

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 德克萨斯大学休斯顿健康科学中心(UTHSC-H)提议在德克萨斯州休斯敦的德克萨斯医学中心(TMC)建立一个临床和转化科学中心(CCTS)。参加CCTS的教员和受训人员将包括来自UTHSC-H部分学位授予学校的教师和学员，包括其医学院、公共卫生学院、生物医学研究生院 来自德克萨斯大学安德森癌症中心(MDACC)的合作教师/机构也设在TMC内。CCTS的学术“家”将位于犹他州理工大学医学院新装修的CCTS指定空间内，面积为11,422平方英尺。 实际加入赫尔曼纪念医院(MHH)，并作为其合作伙伴和主要教学医院。CCTS“总部”将管理CCTS的所有方面，并为教职员工和受训人员提供空间和资源，以及研究设计、生物统计学、监管问题、伦理学和生物信息学方面的专业知识，并为试点和可行性研究提供资金，提供资源和保护时间 临床和翻译教师和实习生以及与不同社区和行业的互动/合作。对于参与者和临床互动资源(PCIR)，CCTS将包括位于MHH的UTHSC-H综合临床研究中心(GCRC)、位于布朗斯维尔的卫星UTHSC-H GCRC、 德克萨斯州，以及部分MDACC临床和翻译研究中心，以提高研究生产力和效率。在其教育部分，CCTS将包括目前的临床研究和循证医学中心，该中心已经开发并目前在UTHSC-H提供正式的课程、指导和临床研究(MCR)硕士学位，并在MDACC获得有效的NCRR K30奖。申请中还提出了一项新的T32申请，提供社区卫生科学硕士和博士学位的组合，主要面向博士后学生的生物医学科学和/或生物医学信息学，以及面向博士后实习生和初级教师的K12申请。CCTS还将包括核心翻译实验室，包括 基因分型/测序Corel提供DNA微阵列、RT-PCR和蛋白质组学服务的Biomarkers核心、免疫监测核心、核磁共振成像核心和生物库核心。CCTS“智囊团”由高水平的翻译和临床研究人员、基础科学家和教育工作者组成，以及 社区代表将聚集在一起，作为“创新引擎”，提出和建议应用新的和新兴的科学信息、方法和技术，以跨专业、学科和社区研究人类健康和疾病。