Center for Clinical and Translational Sciences

临床和转化科学中心

• 批准号: 8138193
• 负责人: David D McPherson
• 金额: $ 16.43万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2011-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8138193
• 关键词: Award; Bioinformatics; Biological Markers; Biometry; Cancer Center; Center for Translational Science Activities; Clinical; Clinical Cancer Center; Clinical Investigator; Clinical Research; Collaborations; Communities; Community Health; DNA Microarray Chip; Dental Schools; Discipline; Disease; Doctor of Medicine; Doctor of Philosophy; Ethics; Evidence Based Medicine; Faculty; Feasibility Studies; Funding; Grant; Health; Health Sciences; Home environment; Hospitals; Human; Image; Immunologic Monitoring; Industry; Information Sciences; Institutes; Laboratories; Magnetic Resonance Imaging; Master' s Degree; Medical center; Mentors; Methods; Molecular Medicine; National Center for Research Resources; Participant; Postdoctoral Fellow; Productivity; Proteomics; Public Health Schools; Research; Research Design; Resources; Reverse Transcriptase Polymerase Chain Reaction; SECTM1 gene; Satellite Hospitals; School Nursing; Schools; Science; Scientist; Services; Students; Teaching Hospitals; Texas; Time; Translational Research; Universities; biomedical informatics; innovation; medical schools; medical specialties; novel; pre-doctoral; square foot

The University of Texas Health Science Center at Houston (UTHSC-H) proposes to establish a Center for Clinical and Translational Sciences (CCTS) in the Texas Medical Center (TMC), Houston, Texas. Participating faculty and trainees in the CCTS will include those from the UTHSC-H component degree granting schools, including its School of Medicine, School of Public Health, Graduate School of Biomedical Sciences, School of Health Information Sciences, School of Nursing, Dental School and Institute of Molecular Medicine (IMM), as well as collaborating faculty/facilities from the UT M.D. Anderson Cancer Center (MDACC) and which also is located in the TMC. The academic "home" for the CCTS will be located in 11,422 sq ft of newly renovated and CCTS-designated space at the UTH Medical School which is physically joined to the Memorial Hermann Hospital (MHH) and serves as its partner and major teaching hospital. The CCTS "home" will administer all aspects of the CCTS and provide space and resources for faculty and trainees, along with expertise in study design, biostatistics, regulatory issues, ethics, and bioinformatics, and funding of Pilot and Feasibility Studies, provision of resources and protected time for clinical and translational faculty and trainees and interactions/collaborations with the various communites and industry. For Participant and Clinical Interactions Resources(PCIR), the CCTS will subsume the UTHSC-H General Clinical Research Center (GCRC) at MHH, the satellite UTHSC-H GCRC at Brownsville, Texas, and, in part, the MDACC Clinical and Translational Research Center to enhance research productivity and efficiency. In its Educational Component, the CCTS will subsume, in part, the current Center for Clinical Researchand Evidence-Based Medicine, which has developed and currently provides formal classes, mentoring, and a Masters Degree in Clinical Research (MCR) at UTHSC-H, and an active NCRR K30 award at MDACC. Also proposed in the application is a novel T32 application offering combinations of Masters and PhD degrees in Community Health Sciences,'Biomedical Sciences and/or Biomedical Informatics, primarily for pre-doctoral students, and a K12 application for post-doctoral trainees andjunior faculty. The CCTS also will subsume Core Translational Laboratories, including a enotyping/Sequencing Corel a Biomarkers Core offering DNA Microarray, RT-PCR and Proteomics services , an Immune Monitoring Core, an MRI Imaging Core, and a Biobanking Core. A CCTS "Think Tank" comprised of highly accomplished translational and clinical Investigators, basic scientists and educators, and community representatives,will come together as an "engine for innovation" to bring forward and recommend the application of novel and emerging scientific information, methods and technologiesto research into human health and diseases across specialties, disciplines and communities. .

德克萨斯大学休斯顿健康科学中心（UTHSC-H）建议建立一个中心， 临床和转化科学（CCTS），德克萨斯州休斯顿德克萨斯医学中心（TMC）。 参与CCTS的教师和学员将包括UTHSC-H部分学位的教师和学员 授予学校，包括其医学院，公共卫生学院，生物医学研究生院 科学，健康信息科学学院，护理学院，牙科学院和研究所 分子医学（IMM），以及来自UT医学博士的合作教师/设施。安德森癌症 中心（MDACC），也位于TMC。CCTS的学术“家”将位于 在UTH医学院新装修的11，422平方英尺和CCT指定的空间， 物理加入纪念赫尔曼医院（MHH），并作为其合作伙伴和主要教学 医院CCTS "家园"将管理CCTS的所有方面，并为以下方面提供空间和资源： 教师和学员，沿着在研究设计，生物统计学，监管问题，伦理学，和 生物信息学，以及资助试点和可行性研究，提供资源和保护时间， 临床和翻译教师和学员以及与各种社区的互动/合作 和行业对于参与者和临床互动资源（PCIR），CCTS将提交 UTHSC-H综合临床研究中心（GCRC）位于MHH，卫星UTHSC-H GCRC位于布朗斯维尔， 德克萨斯州，以及部分MDACC临床和转化研究中心，以加强研究 生产力和效率。在其教育部分，CCTS将部分支持目前的 临床研究和循证医学中心，已经开发并目前提供 正式的课程，指导，并在临床研究硕士学位（MCR）在UTHSC-H，和一个积极的 MDACC的NCRR K30奖。该申请还提出了一种新型T32应用产品 硕士和博士学位的组合在社区健康科学，生物医学科学和/或 生物医学信息学，主要面向博士前学生，以及博士后学员的K12申请 和初级教员。CCTS还将资助核心翻译实验室，包括一个 基因分型/测序Corel a Biomarkers Core提供DNA微阵列、RT-PCR和蛋白质组学 服务，免疫监测核心，MRI成像核心和生物库核心。CCTS "智囊团" 由高度成就的翻译和临床研究者，基础科学家和教育工作者组成， 社区代表，将作为"创新引擎"聚集在一起， 建议应用新的和新兴的科学信息、方法和技术， 跨专业、学科和社区的人类健康和疾病研究。.

项目成果

Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.

• DOI: 10.1002/jcp.23035
• 发表时间: 2012-07
• 期刊: JOURNAL OF CELLULAR PHYSIOLOGY
• 影响因子: 5.6
• 作者: Liu, Qi;Xi, Yutao;Terry, Toya;So, Shui-Ping;Mohite, Anita;Zhang, Jia;Wu, Geru;Liu, Xiaobing;Cheng, Jie;Ruan, Ke-He;Willerson, James T.;Dixon, Richard A. F.
• 通讯作者: Dixon, Richard A. F.

Hepatic arterial infusion therapy in advanced cancer and liver-predominant disease: the MD Anderson Experience.

• DOI: 10.5754/hge12257
• 发表时间: 2013-10
• 期刊: Hepato-gastroenterology
• 作者: A. Tsimberidou;C. Vaklavas;S. Fu;S. Wen;Joann Lim;D. Hong;J. Wheler;A. Naing;C. Uehara;M. Wallace;R. Kurzrock

Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?

• DOI: 10.3324/haematol.2011.057752
• 发表时间: 2012-06-01
• 期刊: HAEMATOLOGICA-THE HEMATOLOGY JOURNAL
• 作者: Tang, Guilin;Zuo, Zhuang;Wang, Sa A.
• 通讯作者: Wang, Sa A.

The burden of non-communicable disease in transition communities in an Asian megacity: baseline findings from a cohort study in Karachi, Pakistan.

• DOI: 10.1371/journal.pone.0056008
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Khan FS;Lotia-Farrukh I;Khan AJ;Siddiqui ST;Sajun SZ;Malik AA;Burfat A;Arshad MH;Codlin AJ;Reininger BM;McCormick JB;Afridi N;Fisher-Hoch SP
• 通讯作者: Fisher-Hoch SP

Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation.

• DOI: 10.1016/j.bbmt.2012.05.014
• 发表时间: 2012-08
• 期刊: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
• 影响因子: 4.3
• 作者: Ma, Qing;Li, Dan;Nurieva, Roza;Patenia, Rebecca;Bassett, Roland;Cao, Wei;Alekseev, Andrei M.;He, Hong;Molldrem, Jeffrey J.;Kroll, Michael H.;Champlin, Richard E.;Sale, George E.;Afshar-Kharghan, Vahid
• 通讯作者: Afshar-Kharghan, Vahid