CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 用于该研究领域的基础设施，而不是直接提供的资金 向子项目或子项目工作人员提供NCRR补助金。 圣路易斯（WU）的华盛顿大学的CTSA申请建立在杰出的生物医学研究，研究培训和患者护理的悠久机构历史之上。WU是构成CTSA基础的4项临床研究和培训赠款的获得者（GCRC，目前处于资助的第46年，以及K12，K30和T32赠款。另一个关键因素是WU在基因组科学，生物成像和临床研究方面的多学科合作研究的新BioMed 21战略计划。所有这些要素将与WU的其他现有资源结合起来，形成一个转型的新临床和转化科学研究所（ICTS）。通过实施本申请中描述的15个关键项目功能，ICTS将在概念上和操作上重塑和重振WU的临床和转化研究以及临床研究培训。与其他学术，医疗保健，社区和科学机构建立前所未有的合作伙伴关系，补充我们在实验室和临床研究以及研究培训方面的核心专业知识，这对ICTS领导的转型至关重要。我们的合作伙伴包括BJC HealthCare，一个综合性的学术和社区医疗保健提供系统;圣刘易斯大学公共卫生学院，研究生院和健康科学Doisy学院;密苏里州大学圣路易斯护理学院;南伊利诺伊大学爱德华兹维尔护理学院;和圣路易斯药学院;主要组织促进社区健康以及生物医学和制药公司在圣路易斯地区。这些资源的结合创造了一个出色的环境，使基础实验室发现，然后可以转化为临床研究方案，并最终通过广泛的社区互动和商业伙伴关系，在临床实践和病人护理的进步。“为了确保信息和通信技术的成功，吴作出了大量的空间和财政支持的承诺。巴恩斯犹太和圣路易斯儿童医院，我们的学术医院合作伙伴和BdC保健，我们的附属卫生系统，也作出了重大承诺的临床研究活动的信息和通信技术。这些额外的资源加上现有的高质量的临床和转化科学计划，确保吴将作出杰出贡献，这NIH的倡议。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. This CTSA application from Washington University in St. Louis (WU) is built on a long institutional history of outstanding biomedical research, research training, and patient care. WU is the recipient of the 4 clinical research and training grants that form the basis of the CTSA (GCRC, currently in its 46th year of funding, and K12, K30, and T32 grants.) Another critical element is WU's new BioMed 21 strategic initiative in multidisciplinary, collaborative research in genome sciences, biological imaging, and clinical investigation. All these elements will be conjoined with other existing resources at WU to form a transformational new Institute of Clinical and Translational Sciences (ICTS). By implementing the 15 key Program Functions described in this application, the ICTS will conceptually and operationally reinvent and reinvigorate clinical and translational research and clinical research training at WU. An unprecedented level of partnership with other academic, healthcare, community and scientific institutions that complement our core expertise in laboratory and clinical research and research training is central to the transformation that will be led by the ICTS. Our partners include BJC HealthCare, an integrated academic and community health care delivery system; Saint Louis University School of Public Health, Graduate School and Doisy College of Health Sciences; University of Missouri St. Louis College of Nursing; Southern Illinois University Edwardsville School of Nursing; and St. Louis College of Pharmacy; key organizations promoting community health as well as biomedical and pharmaceutical companies in the St. Louis area. The coupling of these resources creates an outstanding environment to make basic laboratory discoveries that can then be translated into clinical research protocols and ultimately into advances in clinical practice and patient care through extensive community interactions and commercial partnerships." To ensure the success of the ICTS, WU has made substantial commitments of space and financial support. Barnes-Jewish and St. Louis Children's Hospitals, our academic hospital-partnersrand-BdC HealthCare, our affiliated health system, have also made substantial commitments to the clinical research activities of the ICTS. These additional resources coupled with the existing high quality programs in clinical and translational science ensure that WU will make outstanding contributions to this NIH initiative.