PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

PS08-002，针对黑人 MSM/W 的 HIV 预防干预措施的开发和测试

• 批准号: 7923154
• 负责人: MARIA ISABEL FERNANDEZ
• 金额: $ 33.33万
• 依托单位: NOVA SOUTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2012-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7923154
• 关键词: PS08; 002; DEV; TESTING; HIV

DESCRIPTION (provided by applicant): In the United States, Blacks continue to be disproportionately impacted by HIV/AIDS. They account for only 13% of the population, yet comprise 51% of new HIV/AIDS cases diagnoses between 2001-2004.65 Black men who have sex with men (MSM), whether they identify themselves as gay, bisexual, or heterosexual are the group most severely impacted by HIV as compared to other high-risk groups. 4 This is particularly true in Chicago, an MSA that ranked fourth among U.S. metropolitan areas in AIDS case rates among Black males in 2004 (the most recent data available).4 Male to male sexual contact is the primary mode of transmission for Black men in Chicago. In 2005, 44% of AIDS cases in Chicago were among MSM and 59% of cases among MSM were Black. The proposed study addresses the HIV prevention needs of Black bisexually-active men (BMSMW) by developing and testing a theoretically based, culturally and contextually appropriate health promotion and HIV risk reduction intervention, Project POWER. POWER, designed to be delivered through face-to-face (FtF) interactions or through the internet in real time, consists of 4 weekly sessions lasting from 60 to 90 minutes. The current application builds on prior successful collaborations between the Senior (Fernandez) and junior (Hosek) investigators, the experienced research team and TaskForce (a CBO with long history of service to BMSMW in the Chicago MSA). We will first finalize the development of POWER in the two delivery modalities and adapt the health promotion control intervention (HEALTH) for BMSMW. We will then conduct a randomized control trial (RCT) to test the acceptability, feasibility and preliminary efficacy of POWER in the two delivery modalities compared with HEALTH. Using respondent driven sampling, we will recruit 300 BMSMW and randomly assign them to one of the 3 conditions. Participants will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention. In addition to examining reductions in unprotected anal and/or vaginal sex episodes, we will examine contextual and cultural factors that may be associated with risk and protection in BMSMW. Throughout the project period, we will collaborate with the multi-site study team by participating in scheduled conference calls, attending meetings, completing assigned tasks, preparing manuscripts, presenting at local, national and international meetings and other work of relevance to the initiative.

描述(申请人提供)：在美国，黑人继续受到艾滋病毒/艾滋病的不成比例的影响。他们只占总人口的13%，但占2001年至2004.65年间新诊断的艾滋病毒/艾滋病病例的51%。与其他高危群体相比，无论他们是男同性恋者、双性恋者还是异性恋者，黑人男性都是受艾滋病毒影响最严重的群体。4芝加哥的情况尤其如此，2004年该州黑人男性艾滋病发病率在美国大都市地区中排名第四(可获得的最新数据)。4在芝加哥，男性与男性之间的性接触是黑人男性的主要传播方式。2005年，芝加哥44%的艾滋病病例是男男性接触者，59%的男性接触者是黑人。拟议的研究通过开发和测试一种理论上、文化上和背景上适当的促进健康和降低艾滋病毒风险的干预措施POWER项目来解决黑人双性恋活跃男性(BMSMW)的艾滋病毒预防需求。Power旨在通过面对面(FTF)互动或通过互联网实时提供，包括每周4次会议，持续时间为60至90分钟。目前的申请建立在高级(费尔南德斯)和初级(Hosek)调查人员、经验丰富的研究团队和特别工作组(芝加哥MSA的一名长期为BMSMW服务的CBO)之间之前成功合作的基础上。我们将首先敲定两种交付方式下的动力开发，并对BMSMW的健康促进控制干预措施(HANTH)进行调整。然后，我们将进行一项随机对照试验(RCT)，以测试POWER在两种给药方式中的可接受性、可行性和初步疗效，并与健康相比较。通过受访者主导的抽样，我们将招募300辆宝马，并随机将他们分配到3个条件中的一个。参与者将使用ACASI完成行为评估，并在基线、即时干预后和干预后3个月提供尿样和血液样本以检测衣原体、淋病和梅毒。除了检查无保护的肛门和/或阴道性交事件的减少外，我们还将检查可能与BMSMW的风险和保护相关的背景和文化因素。在整个项目期间，我们将与多地点研究小组合作，参加预定的电话会议、出席会议、完成分配的任务、编写手稿、在地方、国家和国际会议上发言以及其他与倡议相关的工作。