PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

描述（由申请人提供）：在美国，黑人继续受到艾滋病毒/艾滋病的不成比例的影响。他们只占人口的13%，却占2001-2004年间新诊断的艾滋病毒/艾滋病病例的51%。65与其他高危人群相比，与男性发生性行为的黑人男性（MSM），无论他们认为自己是同性恋、双性恋还是异性恋，都是受艾滋病毒影响最严重的群体。这在芝加哥尤其如此，2004年芝加哥黑人男性艾滋病发病率在美国大城市中排名第四（最新数据）男性之间的性接触是芝加哥黑人男性传播的主要方式。2005年，芝加哥44%的艾滋病病例是男男性行为者，男男性行为者中59%是黑人。拟议的研究解决了黑人双性恋活跃男性（BMSMW）的艾滋病毒预防需求，通过开发和测试一个有理论基础的，文化和情境适当的健康促进和艾滋病毒风险降低干预，项目权力。POWER旨在通过面对面（FtF）互动或通过互联网实时交付，由每周4次的课程组成，持续时间为60至90分钟。目前的应用程序建立在高级（Fernandez）和初级（Hosek）调查员、经验丰富的研究团队和TaskForce（一个长期服务于芝加哥MSA BMSMW的CBO）之间的成功合作基础上。我们将首先确定POWER在两种分娩方式中的发展，并将健康促进控制干预（health）用于BMSMW。然后，我们将进行一项随机对照试验（RCT），以比较POWER在两种分娩方式中的可接受性、可行性和初步疗效。采用被调查者驱动的抽样方法，我们将招募300名BMSMW，并将他们随机分配到3个条件中的一个。参与者将使用ACASI完成行为评估，并在基线、干预后立即和干预后3个月提供尿液和血液样本以检测衣原体、淋病和梅毒。除了检查无保护肛交和/或阴道性交次数的减少，我们还将检查可能与BMSMW的风险和保护相关的背景和文化因素。在整个项目期间，我们将与多地点研究团队合作，参加预定的电话会议，参加会议，完成分配的任务，准备手稿，在当地，国家和国际会议上发表演讲，以及其他与该倡议相关的工作。

DESCRIPTION (provided by applicant): In the United States, Blacks continue to be disproportionately impacted by HIV/AIDS. They account for only 13% of the population, yet comprise 51% of new HIV/AIDS cases diagnoses between 2001-2004.65 Black men who have sex with men (MSM), whether they identify themselves as gay, bisexual, or heterosexual are the group most severely impacted by HIV as compared to other high-risk groups. 4 This is particularly true in Chicago, an MSA that ranked fourth among U.S. metropolitan areas in AIDS case rates among Black males in 2004 (the most recent data available).4 Male to male sexual contact is the primary mode of transmission for Black men in Chicago. In 2005, 44% of AIDS cases in Chicago were among MSM and 59% of cases among MSM were Black. The proposed study addresses the HIV prevention needs of Black bisexually-active men (BMSMW) by developing and testing a theoretically based, culturally and contextually appropriate health promotion and HIV risk reduction intervention, Project POWER. POWER, designed to be delivered through face-to-face (FtF) interactions or through the internet in real time, consists of 4 weekly sessions lasting from 60 to 90 minutes. The current application builds on prior successful collaborations between the Senior (Fernandez) and junior (Hosek) investigators, the experienced research team and TaskForce (a CBO with long history of service to BMSMW in the Chicago MSA). We will first finalize the development of POWER in the two delivery modalities and adapt the health promotion control intervention (HEALTH) for BMSMW. We will then conduct a randomized control trial (RCT) to test the acceptability, feasibility and preliminary efficacy of POWER in the two delivery modalities compared with HEALTH. Using respondent driven sampling, we will recruit 300 BMSMW and randomly assign them to one of the 3 conditions. Participants will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention. In addition to examining reductions in unprotected anal and/or vaginal sex episodes, we will examine contextual and cultural factors that may be associated with risk and protection in BMSMW. Throughout the project period, we will collaborate with the multi-site study team by participating in scheduled conference calls, attending meetings, completing assigned tasks, preparing manuscripts, presenting at local, national and international meetings and other work of relevance to the initiative.