PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

描述（由申请人提供）：在美国，黑人继续受到艾滋病毒/艾滋病的不成比例的影响。他们只占人口的13%，但却占2001- 2004年期间新诊断的艾滋病毒/艾滋病病例的51%。65与其他高危群体相比，与男子发生性关系的黑人男子，无论他们认为自己是同性恋、双性恋还是异性恋，都是受艾滋病毒影响最严重的群体。4这在芝加哥尤其如此，2004年（最新可用数据），在美国大都市地区中，该MSA黑人男性艾滋病病例率排名第四。4男性对男性的性接触是芝加哥黑人男性的主要传播方式。2005年，芝加哥44%的艾滋病病例是男男性行为者，59%的男男性行为者是黑人。这项拟议的研究通过开发和测试一种基于理论的，文化和背景适当的健康促进和降低艾滋病毒风险的干预措施，解决了黑人双性恋活跃男性（BMSMW）的艾滋病毒预防需求。POWER旨在通过面对面（FtF）互动或通过互联网在真实的时间内提供，包括每周4次，持续60至90分钟。当前的应用程序建立在高级（费尔南德斯）和初级（Hosek）调查员，经验丰富的研究团队和工作组（一个CBO与长期服务于芝加哥MSA的BMSMW）之间的成功合作基础上。我们会先完成发展两种模式下的“增强能力”计划，并为《强制性小型工程条例》采用健康促进及控制介入措施。然后，我们将进行一项随机对照试验（RCT），以测试POWER在两种分娩方式中与HEALTH相比的可接受性、可行性和初步疗效。我们会以受访者主导抽样方式，招募300名建筑物管理及法定最低工资工人，并将他们随机分配至3个条件之一。参与者将使用ACASI完成行为评估，并在基线、干预后即刻和干预后3个月提供尿液和血液样本以检测衣原体、淋病和梅毒。除了检查减少无保护的肛门和/或阴道性交事件，我们将研究上下文和文化因素，可能与BMSMW的风险和保护。在整个项目期间，我们将通过参加预定的电话会议，参加会议，完成分配的任务，准备手稿，在地方，国家和国际会议上发表演讲以及与该倡议相关的其他工作，与多地点研究小组合作。

DESCRIPTION (provided by applicant): In the United States, Blacks continue to be disproportionately impacted by HIV/AIDS. They account for only 13% of the population, yet comprise 51% of new HIV/AIDS cases diagnoses between 2001-2004.65 Black men who have sex with men (MSM), whether they identify themselves as gay, bisexual, or heterosexual are the group most severely impacted by HIV as compared to other high-risk groups. 4 This is particularly true in Chicago, an MSA that ranked fourth among U.S. metropolitan areas in AIDS case rates among Black males in 2004 (the most recent data available).4 Male to male sexual contact is the primary mode of transmission for Black men in Chicago. In 2005, 44% of AIDS cases in Chicago were among MSM and 59% of cases among MSM were Black. The proposed study addresses the HIV prevention needs of Black bisexually-active men (BMSMW) by developing and testing a theoretically based, culturally and contextually appropriate health promotion and HIV risk reduction intervention, Project POWER. POWER, designed to be delivered through face-to-face (FtF) interactions or through the internet in real time, consists of 4 weekly sessions lasting from 60 to 90 minutes. The current application builds on prior successful collaborations between the Senior (Fernandez) and junior (Hosek) investigators, the experienced research team and TaskForce (a CBO with long history of service to BMSMW in the Chicago MSA). We will first finalize the development of POWER in the two delivery modalities and adapt the health promotion control intervention (HEALTH) for BMSMW. We will then conduct a randomized control trial (RCT) to test the acceptability, feasibility and preliminary efficacy of POWER in the two delivery modalities compared with HEALTH. Using respondent driven sampling, we will recruit 300 BMSMW and randomly assign them to one of the 3 conditions. Participants will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention. In addition to examining reductions in unprotected anal and/or vaginal sex episodes, we will examine contextual and cultural factors that may be associated with risk and protection in BMSMW. Throughout the project period, we will collaborate with the multi-site study team by participating in scheduled conference calls, attending meetings, completing assigned tasks, preparing manuscripts, presenting at local, national and international meetings and other work of relevance to the initiative.