PS08-002, DEV AND TESTING OF HIV PREV INTERVENTION TARGETING BLACK MSM/W

PS08-002，针对黑人 MSM/W 的 HIV 预防干预措施的开发和测试

• 批准号: 8142973
• 负责人: MARIA ISABEL FERNANDEZ
• 金额: $ 29.17万
• 依托单位: NOVA SOUTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8142973
• 关键词: PS08; 002; DEV; TESTING; HIV

DESCRIPTION (provided by applicant): In the United States, Blacks continue to be disproportionately impacted by HIV/AIDS. They account for only 13% of the population, yet comprise 51% of new HIV/AIDS cases diagnoses between 2001-2004.65 Black men who have sex with men (MSM), whether they identify themselves as gay, bisexual, or heterosexual are the group most severely impacted by HIV as compared to other high-risk groups. 4 This is particularly true in Chicago, an MSA that ranked fourth among U.S. metropolitan areas in AIDS case rates among Black males in 2004 (the most recent data available).4 Male to male sexual contact is the primary mode of transmission for Black men in Chicago. In 2005, 44% of AIDS cases in Chicago were among MSM and 59% of cases among MSM were Black. The proposed study addresses the HIV prevention needs of Black bisexually-active men (BMSMW) by developing and testing a theoretically based, culturally and contextually appropriate health promotion and HIV risk reduction intervention, Project POWER. POWER, designed to be delivered through face-to-face (FtF) interactions or through the internet in real time, consists of 4 weekly sessions lasting from 60 to 90 minutes. The current application builds on prior successful collaborations between the Senior (Fernandez) and junior (Hosek) investigators, the experienced research team and TaskForce (a CBO with long history of service to BMSMW in the Chicago MSA). We will first finalize the development of POWER in the two delivery modalities and adapt the health promotion control intervention (HEALTH) for BMSMW. We will then conduct a randomized control trial (RCT) to test the acceptability, feasibility and preliminary efficacy of POWER in the two delivery modalities compared with HEALTH. Using respondent driven sampling, we will recruit 300 BMSMW and randomly assign them to one of the 3 conditions. Participants will complete behavioral assessments using ACASI and provide urine and blood specimens to test for chlamydia, gonorrhea, and syphilis at baseline, immediate post and 3 month post intervention. In addition to examining reductions in unprotected anal and/or vaginal sex episodes, we will examine contextual and cultural factors that may be associated with risk and protection in BMSMW. Throughout the project period, we will collaborate with the multi-site study team by participating in scheduled conference calls, attending meetings, completing assigned tasks, preparing manuscripts, presenting at local, national and international meetings and other work of relevance to the initiative.

描述（由申请人提供）：在美国，黑人继续受到艾滋病毒/艾滋病的严重影响。他们只占总人口的 13%，但却占 2001 年至 2004 年间新诊断的艾滋病毒/艾滋病病例的 51%。65 与其他高危群体相比，男男性行为者 (MSM) 的黑人，无论他们自认为是同性恋、双性恋还是异性恋，都是受艾滋病毒影响最严重的群体。 4 在芝加哥尤其如此，2004 年，该州黑人男性艾滋病发病率在美国大都市区中排名第四（最新可用数据）。4 男性之间的性接触是芝加哥黑人男性的主要传播方式。 2005年，芝加哥44%的艾滋病病例发生在MSM中，59%的MSM病例是黑人。拟议的研究通过开发和测试基于理论、文化和背景适当的健康促进和艾滋病毒风险降低干预措施“Project POWER”，解决了黑人双性恋活跃男性 (BMSMW) 的艾滋病毒预防需求。 POWER 旨在通过面对面 (FtF) 互动或通过互联网实时提供，由每周 4 次的课程组成，持续时间从 60 到 90 分钟不等。当前的应用程序建立在高级 (Fernandez) 和初级 (Hosek) 研究人员、经验丰富的研究团队和 TaskForce（长期为芝加哥 MSA BMSMW 服务的 CBO）之间先前成功合作的基础上。我们将首先完成两种交付方式的 POWER 开发，并调整 BMSMW 的健康促进控制干预措施 (HEALTH)。然后我们将进行随机对照试验（RCT），以测试 POWER 与 HEALTH 相比在两种交付方式中的可接受性、可行性和初步疗效。使用受访者驱动抽样，我们将招募 300 名 BMSMW 并将他们随机分配到 3 种情况之一。参与者将使用 ACASI 完成行为评估，并提供尿液和血液样本，以在基线、干预后即刻和干预后 3 个月检测衣原体、淋病和梅毒。除了研究无保护肛交和/或阴道性交次数的减少外，我们还将研究可能与 BMSMW 风险和保护相关的背景和文化因素。在整个项目期间，我们将与多地点研究团队合作，参加预定的电话会议、出席会议、完成分配的任务、准备手稿、在地方、国家和国际会议上发言以及与该倡议相关的其他工作。