SysCODE: Systems-based Consortium for Organ Design and Engineering Leadership Mo

SysCODE：基于系统的器官设计和工程领导联盟

• 批准号: 7928936
• 负责人: RICHARD L MAAS
• 金额: $ 114.14万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-20 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7928936
• 关键词: Address; Biomedical Engineering; Boston; Cells; Complex; Development; Developmental Biology; Device or Instrument Development; Discipline; Engineering; Genetic; Genome; Goals; Heart Valves; Hospitals; In Vitro; Islets of Langerhans; Knowledge; Lead; Leadership; Mechanics; Medicine; Methods; Molecular; Mus; Nodal; Organ; Organogenesis; Physiological; Population; Property; Recruitment Activity; Regulator Genes; Science; Scientist; Signal Transduction; Stem cells; Strategic Planning; System; Tissue Engineering; Tissues; Tooth Germ; Transplantation; Universities; Vision; Work; base; design; engineering design; human morbidity; meetings; organ regeneration

Project Summary Permanent damage to organs and their constituent parts is a major cause of human morbidity. While the need for organ regeneration is partly addressed by transplantation and bioengineered materials and devices, the development of a systematic method to generate new organs and organ parts would transform medicine. At present, however, there is no unified discipline that integrates knowledge about organogenesis, gene regulatory networks, progenitor cells and tissue engineering into a systematic, non-empiric framework that can be used to synthesize organs in vitro. Despite their different functions, many mammalian organs develop by common mechanisms that involve the sequential, ordered exchange of signals befween interacting cell populations, resulting in their progressive differentiation. We hypothesize that the complex, dynamic regulatory networks that underlie endogenous organ development can be resolved at the genetic and ultimately molecular level by the integration of different scientific disciplines, and that this information can be used in the form of a "molecular blueprint" to design and build organ precursors and parts. The Systems-based Consortium for Organ Design and Engineering (SysCODE) will focus on the synthesis of three murine organ components: the tooth germ, pancreatic islet and heart valve. These developing tissues represent both graded levels of complexity and the acquisition of distinct mechanical, physiologic and dynamic properties. To accomplish this ambitious goal, the Consortium will require the formation of new interdisciplines that lie at the nodal points between developmental biology, computational and genome science, and tissue engineering. To this end, we have recruited 24 exceptional scientists from Harvard and its affiliated Hospitals, MIT, Vanderbilt and Boston University who encompass the necessary expertise and who share a common vision of working together as an integrated scientific team to achieve this compelling goal. This U54 Leadership and Management Module describes the grand challenge of organ engineering, the scientific and administrative components that this Consortium has now assembled to meet the challenge, and the strategic plan for how this Consortium will do so. This Consortium will lead in the development of a new paradigm for interdisciplinary science, and build organ'parts in a way that will transform medicine.

项目摘要 器官及其组成部分的永久性损害是人类发病的一个主要原因。而当 器官再生的需要部分通过移植和生物工程材料和设备来解决， 开发一种系统的方法来产生新的器官和器官部分将改变医学。 然而，目前还没有一个统一的学科来整合关于器官发生、基因的知识。 将调控网络、祖细胞和组织工程整合到一个系统的、非经验性的框架中 可以用来在体外合成器官。尽管它们的功能不同，但许多哺乳动物的器官 通过涉及信号之间的顺序、有序交换的公共机制来开发 相互作用的细胞群体，导致它们的渐进分化。我们假设这个建筑群， 作为内源性器官发育基础的动态调控网络可以在基因层面得到解决 最终通过不同科学学科的整合，在分子水平上，这些信息 可以以“分子蓝图”的形式设计和制造器官前体和器官部件。 基于系统的器官设计和工程联盟(SysCODE)将专注于 小鼠牙胚、胰岛和心脏瓣膜三种器官成分的合成。这些 发育中的组织既代表了复杂程度的分级，也代表了对不同机械、 生理和动力学特性。为了实现这一雄心勃勃的目标，财团将要求 形成新的交叉学科，这些学科位于发育生物学、计算生物学和 以及基因组科学和组织工程。为此，我们招募了24名杰出的科学家 哈佛及其附属医院、麻省理工学院、范德比尔特和波士顿大学 拥有专业知识并拥有共同愿景的人，作为一个综合科学团队共同努力，以实现 这个令人信服的目标。这个U54领导和管理模块描述了机构面临的重大挑战 工程，科学和管理部分，该联盟现在已经组装起来，以满足 挑战，以及该联盟将如何做到这一点的战略计划。该财团将在 发展跨学科科学的新范式，并以一种 改变医学。