Linking Parent Drug Use and Child Development Across Three Generations

描述(由申请人提供)：这是一份研究父母和祖父母使用药物对儿童和青少年发育的影响和作用机制的申请。我们寻求5年的支持，以收集和分析西雅图社会发展项目(SSDP)小组成员子女的数据。SSDP(J.David Hawkins，PI)是一项理论驱动的研究，早期嵌套了预防性干预。跨代项目(TIP，Karl G.Hill，PI)研究了SSDP成员的长子、SSDP G2父母自己及其伴侣。早期的工作重点是父母使用药物对孩子的影响。随着大多数G3儿童过渡到青春期，我们建议进行一项后续研究，将数据收集和分析扩展到另外三波。这将提供足够的样本量，以检验1)父母和祖父母及祖父母和祖父母以前和现在使用药物对发育和药物使用开始的影响，2)父母和祖父母和祖父母以前和现在使用药物可能影响儿童发展和药物使用开始的机制，以及3)G2在儿童时期经历的预防性干预对G3‘S发展环境、G2’S育儿做法和G3‘S发展结果的影响程度。这项研究建立在现有的20年纵向研究的基础上，并将与其延伸到30年的S平行进行，没有科学或预算上的重叠。这项拟议的研究提供了一个独特的机会，可以检查三代人之间的药物使用关联因素，并分析G2的S在青春期和成年早期使用药物对他们的育儿行为和子女结局的影响。研究结果将促进对青春期和成年期早期父母和祖父母使用药物对儿童发育、行为和药物使用开始的影响的了解，并将为旨在打破药物使用代际传播循环的预防性干预措施的设计提供具体目标。 公共卫生相关性：这项研究将促进对青春期和成年早期父母和祖父母使用药物对儿童发育、行为和开始使用药物的影响的了解，并将为旨在打破药物使用代际传播循环的预防性干预措施的设计提供具体目标。

DESCRIPTION (provided by applicant): This is an application to examine the effects and mechanisms of action of parental and grandparental drug use on child and adolescent development. We seek 5 years of support to collect and analyze data on the children of the members of the Seattle Social Development Project (SSDP) panel. SSDP (J. David Hawkins, PI) is a theory-driven study with a preventive intervention nested within its early years. The Intergenerational Project (TIP, Karl G. Hill, PI) has studied the firstborn children of SSDP members, the SSDP G2 parents themselves, and their partners. Earlier work focused on effects of parent drug use on children. We propose a follow-up study to extend data collection and analysis for an additional three waves as most G3 children transition into adolescence. This will provide adequate sample sizes for examination of 1) the impact of prior and current parental and grandparental drug use on development and drug use initiation, 2) mechanisms through which prior and current parental and grandparental drug use may affect child development and drug use initiation, and 3) the degree to which benefits from preventive intervention experienced by G2 when they were children affect G3's developmental environment, G2's parenting practices, and G3's developmental outcomes. The study builds on an existing 20-year longitudinal study, and will run parallel to its extension into the 30's, without scientific or budgetary overlap. The proposed study presents a unique opportunity to examine factors linking drug use across three generations and to analyze the effects of G2's drug use during adolescence and early adulthood on their parenting behaviors and on their children's outcomes. Study findings will advance understanding of the effects of parental and grandparental drug use during adolescence and early adulthood on children's development, behavior, and drug use initiation and will provide specific targets for the design of preventive interventions aimed at breaking cycles of intergenerational transmission of drug use. PUBLIC HEALTH RELEVANCE: The study will advance understanding of the effects of parental and grandparental drug use during adolescence and early adulthood on children's development, behavior, and drug use initiation and will provide specific targets for the design of preventive interventions aimed at breaking cycles of intergenerational transmission of drug use.