Development and use of a sheep model to test a novel anti-scoliosis device

开发并使用绵羊模型来测试新型防脊柱侧弯装置

• 批准号: G0700918/1
• 负责人: John Gibson
• 金额: $ 22.64万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0700918%2F1
• 关键词: Development; use; sheep; model; test

Idiopathic scoliosis is a common condition affecting primarily young girls aged 11-14 years, but also boys and younger children They develop a progressive spinal curvature that is disfiguring and in it severest form potentially fatal. Treatment in the 1950s - 1960s consisted of lying the patient in a plaster mould for many months until the vertebra spontaneously fused together. This method of management was replaced in the 1970s by instrumented fusion of the spine, due to the availability of sophisticated spinal implants and improvements in anaesthesia. This latter method, used until today, does provide some curve correction and limits the period of patient hospitalisation. Unfortunately, a significant curvature, often in excess of 30 degrees, will remain and the child is often left with a fusion extending from the upper thoracic to lower lumbar region. In addition, a number of patients who underwent spinal fusion are presenting to the adult spinal clinic with degenerate change in the segments below their fusions. This will be a source of severe pain in later life. This project aims to investigate whether a novel device may be implanted on the convexity of a developing scoliosis curve and by using natural growth cause the curvature to swing back into neutral alignment. It is unique in design and although shown to work in a spinal model completely unproven in vivo. The researchers seek grant funding for proof of the concept with an animal model. This is clearly essential before any use of the device in a child.

特发性脊柱侧凸是一种常见病，主要影响11-14岁的年轻女孩，但也影响男孩和更小的儿童。他们会发展为进行性脊柱弯曲，毁容，最严重的形式可能致命。20世纪50年代至60年代的治疗方法包括将患者躺在石膏模具中数月，直到椎体自然融合在一起。由于先进的脊柱植入物和麻醉技术的改进，这种治疗方法在20世纪70年代被脊柱内固定融合术所取代。后一种方法至今仍在使用，它确实提供了一些曲线校正，并限制了患者住院的时间。不幸的是，明显的弯曲，通常超过30度，仍然存在，儿童通常会留下从上胸椎延伸到下腰椎的融合。此外，许多接受脊柱融合术的患者在成人脊柱诊所出现融合下节段退行性改变。这将成为日后生活中严重痛苦的根源。该项目旨在研究一种新型装置是否可以植入发展中的脊柱侧凸曲线的凸面上，并通过自然生长使曲率摆动回中性对齐。它在设计上是独特的，虽然在脊髓模型中显示工作，但在体内完全未经证实。研究人员寻求拨款，用动物模型证明这一概念。在儿童使用该设备之前，这显然是必要的。