Identifying early molecular changes underlying familial Alzheimer’s disease

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Analysis of our unique genetic model of inherited, familial Alzheimer’s disease (fAD) using advanced molecular, computational and behavioural techniques is revealing dramatic, early changes in brain function long before the disease would occur. We will expand our work to compare our first model with a model of the most common fAD mutation E280A “Paisa” from Columbia. Commonalities between the models will help us identify the initial stresses that cause Alzheimer’s disease.