Conversion Disorder: A Cognitive Neuropsychiatric Approach

转换障碍：一种认知神经精神病学方法

• 批准号: G0701055/1
• 负责人: Anthony David
• 金额: $ 30.74万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701055%2F1
• 关键词: Conversion; Disorder; Cognitive; Neuropsychiatric; Approach

Conversion disorder (?hysteria?) is a very common, very disabling condition, which is thought to occur when emotional problems are ?converted? into physical symptoms such as paralysis or blindness. Though it is as common and as disabling as ever, there has been very little research on it since the 19th century. The process by which it occurs remains mysterious, and there are no established treatments. Most patients with the disorder do not believe they have it, and do not see their problems as mental at all. We wish to examine this conversion process to see if it has some basis in modern neuroscience. If the conversion model is correct, then we would expect patients to have more life stresses of certain types leading up to their developing the disorder. This can be difficult to prove because of the unreliability of people?s recall, and because we know this group tend to deny the relevance of such stresses. We propose to address this with a standardised interview, the Life Events & Difficulties Schedule, which is a valid and reliable way of accessing problems from subjects? pasts. The conversion model proposes that these experiences are emotionally repressed. Using brain scanning, we wish to examine patients while they recall those experiences to see if they do recall them in a less emotional way than other people, even though this may be something they do not acknowledge. We will also examine whether recall brings on their symptoms - making their paralysis worse, for example. If this is successful we expect it will make the diagnosis much more acceptable and understandable to patients, and open the field to the research it sorely needs.

转换障碍（“癔症”）是一种非常常见、非常令人丧失能力的病症，人们认为当情绪问题“转换”时就会发生这种情况。导致瘫痪或失明等身体症状。尽管它一如既往地常见且造成障碍，但自 19 世纪以来对其进行的研究却很少。它发生的过程仍然很神秘，并且没有既定的治疗方法。大多数患有这种疾病的患者并不相信自己患有这种疾病，并且根本不认为他们的问题是精神问题。我们希望研究这个转换过程，看看它是否有现代神经科学的基础。如果转换模型是正确的，那么我们预计患者会承受更多某些类型的生活压力，从而导致他们患上这种疾病。这可能很难证明，因为人们的回忆不可靠，而且我们知道这个群体倾向于否认此类压力的相关性。我们建议通过标准化访谈（生活事件和困难时间表）来解决这个问题，这是从受试者那里获取问题的有效且可靠的方式？过去。转换模型提出这些经历在情感上受到压抑。通过大脑扫描，我们希望在患者回忆这些经历时对其进行检查，看看他们是否确实以比其他人不那么情绪化的方式回忆这些经历，即使他们可能不承认这一点。我们还将检查回忆是否会带来他们的症状，例如使他们的瘫痪更加严重。如果成功，我们预计它将使诊断更容易为患者所接受和理解，并为其迫切需要的研究打开新的领域。