Digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for Binge Eating Disorder

数字正念冥想增强认知行为疗法（CBT-MM）治疗暴食症

• 批准号: 10661161
• 负责人: Margarita Sala
• 金额: $ 15.41万
• 依托单位: YESHIVA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10661161
• 关键词: Address; Affect; Aftercare; American; Area; Award; Behavioral; Benchmarking; Binge Eating; Binge eating disorder; Clinical; Cognitive Therapy; Combined Modality Therapy; Conduct Clinical Trials; Development; Disease; Disease remission; Eating; Eating Disorders; Elements; Eligibility Determination; Emotions; Feedback; Frequencies; Guidelines; Health Services Accessibility; Individual; Intervention; Interview; Length; Logistics; Maintenance; Measures; Meditation; Mental Depression; Mentorship; Mindfulness Training; Monitor; National Center for Complementary and Integrative Health; Obesity; Outcome; Overweight; Participant; Pathway interactions; Phase; Population; Protocols documentation; Public Health; Qualitative Methods; Quality of life; Randomized; Randomized, Controlled Trials; Research; Research Project Grants; Role; Shapes; Source; Specialist; Symptoms; System; Technology; Testing; Training; Transportation; Wait Time; Weight; acceptability and feasibility; career; cognitive enhancement; comparative efficacy; cost; depressive symptoms; dietary; digital; digital delivery; digital treatment; effective therapy; efficacy evaluation; emotion dysregulation; follow up assessment; follow-up; improved; indexing; innovation; mindfulness; mindfulness meditation; novel; primary outcome; prototype; psychosocial; recruit; relapse patients; skills; smartphone application; theories; therapy development; trait; usability; user centered design; virtual; web app

PROJECT SUMMARY/ABSTRACT Binge eating disorder (BED) is a prevalent disorder, affecting 3.5% of Americans. BED is maintained by two- pathways: (1) dietary over-restriction and (2) emotion dysregulation. Current treatments for BED, such as Cognitive Behavioral Therapy (CBT) produce suboptimal results because they only target over-restriction. Mindfulness meditation (MM) targets emotion dysregulation and could thus be an important addition to CBT for Eating Disorders. Furthermore, digital delivery of an MMT for BED would offer unprecedented scalability, but there are no current digital MMTs for BED. The current K23 proposal involves developing a digital Mindfulness Meditation-enhanced Cognitive Behavioral Therapy (CBT-MM) for BED via two phases. CBT-MM will target the two different mechanisms of BED (dietary over-restriction and emotion dysregulation). In Phase 1, I will finalize the development of digital CBT-MM via interview-based user testing. In Phase 2, I will conduct a pilot feasibility randomized controlled trial (RCT). For the RCT, 40 individuals with BED recruited nationally will be randomized to digital: 1) CBT-MM (n = 20); or 2) an already developed digital CBT treatment (iTakeControl) only (n = 20). The RCT will be conducted virtually, with video-based assessments at baseline, mid- and post-treatment, and 3-month follow up. Aim 1 is to develop digital CBT-MM. Aim 2 is to evaluate feasibility and acceptability. Aim 3 is to measure within-group changes from pre-to post treatment on binge eating remission, binge eating frequency, weight, quality of life, depressive symptoms, emotion dysregulation, dietary over-restriction, and trait mindfulness. This project has the potential for developing an innovative, theory-driven, efficacious, and scalable mindfulness-based treatment for BED that can have a large public health impact. To carry out this K23, I will receive mentorship from a leading team of experts in the areas of mindfulness, CBT for eating disorders, technology-based treatment development, and qualitative methods. This K23 will specifically facilitate my training in: (1) developing and refining mindfulness-based eating and weight disorder treatments; (2) technology-based treatment development, (3) formalized training in conducting clinical trials, and (4) qualitative methods for intervention development. This award will serve as a launching point for my career as I leverage the training and research skills afforded by this award to become a leader in the field of digital mindfulness-based treatment development for eating and weight disorders.

项目摘要/摘要 暴食症（BED）是一种流行的疾病，影响3.5%的美国人。床是由两个- 途径：（1）饮食过度限制和（2）情绪失调。目前的治疗床，如 认知行为疗法（CBT）产生次优结果，因为它们只针对过度限制。 正念冥想（MM）针对情绪失调，因此可能成为CBT的重要补充， 饮食失调。此外，用于BED的MMT的数字交付将提供前所未有的可扩展性， 目前没有用于BED的数字MMT。目前的K23提案涉及开发数字正念 冥想增强认知行为疗法（CBT-MM）通过两个阶段治疗BED。CBT-MM将针对 BED的两种不同机制（饮食过度限制和情绪失调）。在第一阶段，我将完成 通过基于访谈的用户测试开发数字CBT-MM。在第二阶段，我将进行试点可行性研究 随机对照试验（RCT）。对于RCT，将在全国范围内招募40名患有BED的个体进行随机化 数字化：1）CBT-MM（n = 20）;或2）仅使用已开发的数字化CBT治疗（iTakeControl）（n = 20）。 RCT将以虚拟方式进行，在基线、治疗中期和治疗后进行基于视频的评估， 3-月跟进。目的一是开发数字化CBT-MM，目的二是评估其可行性和可接受性。目标3 是测量从治疗前到治疗后暴饮暴食缓解、暴饮暴食 频率、体重、生活质量、抑郁症状、情绪失调、饮食过度限制，以及 特质正念该项目有潜力开发一个创新的，理论驱动的，有效的， 可扩展的基于正念的BED治疗，可以产生巨大的公共卫生影响。开展这项 K23，我将接受正念领域领先的专家团队的指导，CBT饮食 疾病，基于技术的治疗开发和定性方法。K23将特别 促进我的培训：（1）开发和完善基于正念的饮食和体重失调治疗; (2)基于技术的治疗开发，（3）进行临床试验的正式培训，以及（4） 干预发展的定性方法。这个奖项将作为我职业生涯的起点，因为我 利用该奖项提供的培训和研究技能，成为数字化领域的领导者 饮食和体重失调的正念治疗开发。