Exploring the Role of Context in Alcohol Craving

探索环境在酒精渴望中的作用

• 批准号: 7899383
• 负责人: PATRICK SHANNON BORDNICK
• 金额: $ 21.12万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7899383
• 关键词: Address; Admission activity; Adult; Alcohol dependence; Alcoholic Beverages; Alcohols; Area; Arousal; Attention; Beer; Behavioral; Biological; Characteristics; Cues; Data; Dependence; Drug Addiction; Drug usage; Environmental Impact; Environmental Risk Factor; Expectancy; Exposure to; Extinction (Psychology); Future; Galvanic Skin Response; Heart Rate; Home environment; Ingestion; Knowledge; Laboratories; Lead; Literature; Measures; Medical; Methodology; Methods; Moods; Outcome; Participant; Patient Self-Report; Patients; Physiological; Psychological reinforcement; Public Health; Randomized; Relapse; Research; Respondent; Role; Simulate; Social Environment; Social Interaction; Societies; Stimulus; Testing; Time; Treatment Failure; Work; addiction; alcohol abuse therapy; alcohol craving; alcohol cue; alcohol expectancy; base; conditioning; cost; craving; cue reactivity; distilled alcoholic beverage; drinking; drug craving; experience; innovation; problem drinker; psychosocial; public health relevance; research study; response; social neuroscience; theories; virtual reality

DESCRIPTION (provided by applicant): Research in addiction is beginning to focus on social neuroscience areas to explore the role of social interactions and environmental contexts in alcohol and drug dependence. To further this work, we proposed to explore the impact of environmental context and proximal alcohol cues in craving and dependence using virtual reality cue reactivity (VRCR). The impact of environmental context and proximal alcohol cues on craving will be tested in a cue reactivity experiment of 200 adult alcohol dependent drinkers. Assignment will be randomized to four environmental context groups who will be exposed to both neutral and alcohol proximal cues. Physiological arousal, subjective craving, attention to cues, relevance of contexts, realism of context, alcohol expectancy and mood state will be compared between groups and three hypotheses concerning the main effects of environmental context and proximal cues will be tested. Results will contribute to the conditioning theory of craving and the effect of environmental context in alcohol and drug dependence. The study results will provide additional information relevant to the generalizability of extinction and other significant issues (reinstatement) in cue reactivity research. Future research building upon the current study can focus on the impact of social interactions across contexts on craving and relapse using VRCR. The ability to manipulate environmental context and social interactions in the lab will provide new methods to study the interaction of context and social influences in alcohol and drug use. PUBLIC HEALTH RELEVANCE: Data from the proposed study will offer information on the role of environmental context in alcohol craving. The effects of alcohol cues and environmental context on craving, physiological reactivity, and attention to cues will be assessed. This study will provide an ecologically validated set of results that will stimulate new behaviorally based research on the treatment of alcohol and drug dependence.

描述（由申请人提供）： 成瘾中的研究开始着重于社会神经科学领域，以探讨酒精和药物依赖性中社会互动和环境环境的作用。为了进一步，我们建议使用虚拟现实提示反应性（VRCR）探索环境环境和近端酒精提示对渴望和依赖的影响。在200名成人酒精饮酒者的提示反应性实验中，将测试环境环境和近端酒精提示对渴望的影响。分配将被随机分为四个环境环境组，这些环境群体将暴露于中性和酒精近端提示。将测试生理唤醒，主观渴望，对线索的关注，背景的相关性，对环境环境和近端提示的主要影响的三个假设，将在组之间进行比较。结果将有助于渴望的调理理论以及环境环境对酒精和药物依赖性的影响。该研究结果将提供与提示反应性研究中灭绝和其他重大问题（恢复）的普遍性有关的其他信息。未来的研究基于当前的研究可以集中于使用VRCR跨环境跨环境对渴望和复发的影响。操纵环境环境和实验室中社会互动的能力将提供新的方法来研究上下文与饮酒中的社会影响的相互作用。 公共卫生相关性： 拟议研究的数据将提供有关环境环境在酒精渴望中作用的信息。酒精提示和环境环境对渴望，生理反应性以及对提示的关注的影响将得到评估。这项研究将提供一组经过生态验证的结果，这些结果将刺激基于行为的新研究，以治疗酒精和药物依赖性。