Virtual Reality Relapse Prevention: Alcohol Dependence

描述（由申请人提供）：在我们的第1阶段资助，我们证明了虚拟现实提示反应系统（VRCR）的可行性，通过生产虚拟现实环境（VRE的），增加了平均450%的酒精主观渴望酒精评估，在40滥用和/或依赖的成年参与者的样本。这项II期研究将VR提示暴露/反应纳入基于复发预防的治疗中。虚拟现实复发预防（VRRP）环境将联合收割机组合描绘在与真实的世界体验一致的上下文中呈现的饮用线索（例如酒精饮料、酒瓶、啤酒）和饮用相关的社交互动（例如在社交环境中被提供饮料、在出售啤酒的便利/加油站周围走动、与酒吧/餐馆的服务员互动）的计算机生成的视频图像。最近的发展将允许将气味线索（例如啤酒，葡萄酒，白酒，食物，香烟烟雾）纳入VR环境中。VRRP的可行性将在酒精依赖饮酒者的门诊临床治疗试验中进行测试。将招募60名酒精依赖成人，并随机分配至VRRP或传统复发预防（TRP）组。一项为期12周的治疗试验将比较VRRP与TRP在治疗和随访期间（1个月、3个月和6个月）的酒精使用、呼吸酒精水平和戒酒率。此外，将使用VR线索反应性评估环境在基线、第6周和第12周评估所有参与者的线索反应性（渴望和生理）。该项目的总体目标是开发和测试VRRP，并开发负担得起的交钥匙VRRP系统，该系统将商业化提供给药物滥用项目，个体治疗师和酒精研究人员，用于酒精和其他药物滥用。 我们建议在第二阶段开发一个酒精依赖的虚拟现实复发预防（VRRP）治疗系统。VRRP将联合收割机与感官输入设备相结合，包括：跟踪设备，视觉头戴式显示器（HMD），气味和定向音频，使参与者沉浸在计算机生成的虚拟环境中。将进行一项比较VRRP与传统复发预防的对照临床治疗研究。

DESCRIPTION (provided by applicant): In our Phase 1 grant, we demonstrated the feasibility of a virtual reality cue reactivity system (VRCR) for alcohol assessment by producing virtual reality environments (VRE's) that increased subjective craving for alcohol on average 450%, in a sample of 40 abusing and/or dependent adult participants. This Phase II study incorporates VR cue exposure/reactivity into a relapse prevention based treatment. Virtual reality relapse prevention (VRRP) environments will combine computer generated video images depicting drinking cues (e.g. alcoholic beverages, liquor bottles, beer) and drinking related social interactions (e.g. being offered a drink in a social setting, walking around a convenience/gas station that sells beer, interacting with a waiter at a bar/restaurant) presented in contexts that are congruent with real world experiences. A recent development will allow the incorporation of scent cues (e.g. beer, wine, liquor, food, cigarette smoke) into the VR environments. The feasibility of VRRP will be tested in an outpatient clinical treatment trial with alcohol dependent drinkers. Sixty alcohol dependent adults will be recruited and randomized to either VRRP or traditional relapse prevention (TRP). A twelve week treatment trial will compare VRRP vs. TRP on alcohol use, breath alcohol levels, and abstinence rates across treatment and follow-up periods (one, three, and six months). In addition, all participants will be assessed for cue reactivity (craving and physiological) at baseline, week six, and week twelve using a VR cue reactivity assessment environment. The overarching aim of this project is to develop and test VRRP, and develop affordable turnkey, VRRP system that will be commercially available to substance abuse programs, individual therapists, and alcohol researchers for alcohol and other drugs of abuse. We proposed to develop in Phase II, a virtual reality relapse prevention (VRRP) treatment system for alcohol dependence. VRRP will combine computer graphics with sensory input devices including: tracking devices, visual head mounted displays (HMD), scents and directional audio to immerse participants in a computer-generated virtual environment. A controlled clinical treatment study comparing VRRP to traditional relapse prevention will be conducted.