University of Houston Drug Abuse Research Development Program

休斯顿大学药物滥用研究发展计划

• 批准号: 8076328
• 负责人: PATRICK SHANNON BORDNICK
• 金额: $ 41.61万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-23 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076328
• 关键词: Address; Adopted; Aging; Applied Research; Area; Basic Science; Centers for Disease Control and Prevention (U.S.); Communities; Data Analyses; Development; Development Plans; Drug Formulations; Drug abuse; Drug usage; Educational Curriculum; Educational workshop; Environment; Epidemiology; Etiology; Faculty; Family; Foundations; Funding; Gentamicins; Goals; Health; Health Services Research; Heroin; Heroin Users; Institution; Interdisciplinary Study; Intervention Studies; Journals; Lead; Leadership; Manuscripts; Measurement; Mediator of activation protein; Mentors; Mentorship; Mexican Americans; Minority; Minority-Serving Institution; Modeling; National Institute of Drug Abuse; Outcome; Peer Review; Pharmaceutical Preparations; Pharmacy facility; Pilot Projects; Policy Maker; Policy Research; Population; Positioning Attribute; Prevention Research; Preventive Intervention; Process; Publications; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Risk Behaviors; Sampling; Schools; Science; Scientist; Services; Social Network; Social Policies; Social Work; Sociology; Structure; Students; System; Target Populations; Training; Translational Research; United States National Institutes of Health; United States Substance Abuse and Mental Health Services Administration; Universities; career; college; comparison group; design; direct application; drug abuse prevention; experience; graduate student; improved; male; metropolitan; multidisciplinary; pharmacokinetic model; population health; programs; psychologic; research and development; response; skills; social; social capital; success; theories; tool; treatment organization

DESCRIPTION (provided by applicant): The University of Houston Drug Abuse Research Development Program (UHDARDP) will increase the capacity of minority faculty and graduate students from the University of Houston (UH) to conduct competitive research on drug abuse. This will be accomplished through the development of a multidisciplinary infrastructure that focus on long-term health and social consequences of injecting heroin use among aging Mexican American males. The research will have implications for drug abuse prevention, intervention, and service theory and practice. Specific aims include: 1) Establish an institutional research development plan to build the capacity to engage in competitive drug research by coalescing resources, leadership, management, and research expertise; 2) Provide a structure for the conceptual, methodological and statistical support to develop minority project directors and graduate students; 3) Execute a multidisciplinary research program consisting of a primary research project and two pilot projects; 4) Recruit other minority project directors and graduate students from UH to develop studies on the health, social, pharmacological and psychological consequences of drug abuse among the target population and provide research experience and scientific information to the community; 5) Bridge the gap between the social and pharmacy sciences in the fields of basic and applied research, and service delivery systems through the development of multidisciplinary translational research courses, curricula and workshops on drug abuse; and 6) Recruit a team of internal and external mentors and consultants from interdisciplinary academic backgrounds to enhance UHDARDPs professional development activities and proposed scientific programs. An organizational infrastructure of complimentary core activities is proposed: Institutional Research Development Plan, Faculty/Project Directors Development Plan, Primary and Pilot Research Projects and a Student Development Plan. The research projects will use a sample of three comparison groups of aging Mexican American heroin users (former in treatment, former not in treatment and current IDU) recruited for the primary research project (N=225). The primary research project examines the drug career, family trajectories and maturing out process in this population in relation to multiple health outcomes and social capital mediators. The first pilot will develop a population pharmacokinetic model to describe and predict the disposition of gentamicin in this population (N=50). The second pilot will use a "network facilitation" model and focus on the extent to which social networks facilitate (or impede) injecting drug use and related risk behaviors (N=60).

描述（由申请人提供）： 休斯顿大学药物滥用研究开发计划（UHDARDP）将提高休斯敦大学（UH）的少数族裔教师和研究生的能力，以进行有关药物滥用的竞争研究。这将通过开发多学科基础设施来实现，该基础设施的重点是在墨西哥裔美国男性中注射海洛因使用的长期健康和社会后果。该研究将对预防药物滥用，干预以及服务理论和实践有影响。具体目的包括：1）制定一项机构研究开发计划，以通过合并资源，领导力，管理和研究专业知识来建立参与竞争性药物研究的能力； 2）为培养少数族裔项目主管和研究生提供概念，方法论和统计支持的结构； 3）执行由主要研究项目和两个试点项目组成的多学科研究计划； 4）招募来自UH的其他少数民族项目主管和研究生，以在目标人群中对药物滥用的健康，社会，药理和心理后果进行研究，并向社区提供研究经验和科学信息； 5）通过开发多学科翻译研究课程，有关药物滥用的课程和讲习班，弥合基础研究和应用程序领域的社会和药学科学之间的差距； 6）招募来自跨学科的内部和外部导师和顾问团队，以增强UHDARDPS的专业发展活动和拟议的科学计划。提出了免费核心活动的组织基础设施：机构研究发展计划，教职员工/项目董事发展计划，初级和试点研究项目以及学生发展计划。研究项目将使用三个比较墨西哥裔美国海洛因使用者的比较组（以前的治疗，以前不在治疗和当前的IDU）中，用于主要研究项目（n = 225）。主要研究项目研究了与多个健康成果和社会资本调解人有关的药物职业，家庭轨迹和整理过程。第一个飞行员将开发人群药代动力学模型，以描述和预测庆大霉素在该人群中的处置（n = 50）。第二名飞行员将使用“网络促进”模型，并专注于社交网络促进（或阻碍）注射药物使用和相关风险行为的程度（n = 60）。