RTE/FDPM for optical imaging of cancer in small animal models
RTE/FDPM 用于小动物模型癌症光学成像
基本信息
- 批准号:7940245
- 负责人:
- 金额:$ 12.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2010-02-05
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAlgorithmsAnimal ModelAnimalsArtsBacterial InfectionsBioluminescenceComputer softwareContrast MediaCouplesCyclotronsDataDevelopmentDiffusionDiseaseDisseminated Malignant NeoplasmEngineeringEquationEvaluationEventFiberFluorescenceFluorescent DyesFrequenciesGene DeliveryGenerationsGoldGovernmentHalf-LifeHeterogeneityHybridsImageIsotopesLabelLightLuciferasesMalignant NeoplasmsMeasurementMedicineMetabolismMethodsModalityModelingMusNoiseNuclearOptical TomographyOpticsPeptidesPersonsPharmacologic SubstancePhasePhotonsPositron-Emission TomographyProcessProductionProteinsRadioRadioactiveRecoveryReporterResearchResolutionSignal TransductionSmall Animal Imaging SystemsSolutionsSourceStem cellsSurfaceSystemTechnologyTestingTexasTherapeutic AgentsTimeUniversitiesValidationVirusVisible RadiationWorkXenograft procedurebasecollegedata acquisitiondetectordrug discoveryfluorophorefundamental researchimage reconstructionimprovedin vivoinhibitor/antagonistlight emissionluciferinmigrationmolecular imagingoptical imagingprofessorradiotracerreconstructionresearch studysimulationsingle photon emission computed tomographysoftware systemstime usetissue reconstructiontomography
项目摘要
Project Summary
In the proposed Phase II research, a commercially viable software reconstruction platform, employing the
solution of the radiative transport equation (RTE), will be developed for accurate and robust in vivo imaging of
fluorescent targets in small animals. Although small animal optical tomography systems have recently been
introduced, current systems do not employ fluorescence or bioluminescence, which have been confined to
planar projections. In addition, current optical tomography systems rely on the use of time independent
measurements and reconstruction algorithms based on the diffusion approximation. However, it is well known
that the small volumes and heterogeneities in mice present conditions where the diffusion approximation is not
valid. Realizing this, transport based solutions of the RTE have been researched as a promising alternative.
However, approaches to date have relied on numerical methods which do not have the accuracy or efficiency
required for commercial deployment. In the Phase I research, Transpire's algorithms for solving the RTE were
successfully applied towards a proof-of-concept process, employing BCM's expertise in frequency-domain
photon migration (FPDM), for reconstruction of fluorophore concentrations in a 3-D mouse phantom. Phase II
research will extend this work to develop an RTE based, tomographic reconstruction software platform for
FDPM photon migration. The specific aims are: (1) to develop an optimized 3-D RTE solver for modeling
excitation and emission light propagation in forward and adjoint modes, streamlined for small animal imaging
conditions with non-contact, non-matching mediums; (2) to develop an adaptive non-linear algorithm employing
forward and adjoint RTE solutions for fluorescence yield reconstructions in small animal volumes; (3) to enable
hybrid microCT/optical imaging by developing automatic grid generation from microCT images; (4) to integrate
the above components into an automated software system for FDPM tomographic reconstruction; and (5) to
quantitative demonstrate commercial viability through imaging of a peptide targeted NIR and visible fluorescent
contrast agent in xenograft mice. Successful completion of Phase II will result in an automated software
product, when combined with BCM's expertise in hardware technologies for frequency-domain fluorescence
small animal imaging, can result in a commercially viable small animal imaging system.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Theranostic nanoshells: from probe design to imaging and treatment of cancer.
- DOI:10.1021/ar200023x
- 发表时间:2011-10-18
- 期刊:
- 影响因子:18.3
- 作者:Bardhan, Rizia;Lal, Surbhi;Joshi, Amit;Halas, Naomi J.
- 通讯作者:Halas, Naomi J.
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{{ truncateString('TODD A WAREING', 18)}}的其他基金
RTE/FDPM for optical imaging of cancer in small animal models
RTE/FDPM 用于小动物模型癌症光学成像
- 批准号:
7219015 - 财政年份:2005
- 资助金额:
$ 12.85万 - 项目类别:
RTE/FDPM for optical imaging of cancer in small animal
RTE/FDPM 用于小动物癌症光学成像
- 批准号:
6934775 - 财政年份:2005
- 资助金额:
$ 12.85万 - 项目类别:
Deterministic Radiotherapy Dose Calculation Method
确定性放疗剂量计算方法
- 批准号:
6883471 - 财政年份:2005
- 资助金额:
$ 12.85万 - 项目类别:
Deterministic Radiotherapy Dose Calculation Method
确定性放疗剂量计算方法
- 批准号:
7465443 - 财政年份:2005
- 资助金额:
$ 12.85万 - 项目类别:
RTE/FDPM for optical imaging of cancer in small animal models
RTE/FDPM 用于小动物模型癌症光学成像
- 批准号:
7499693 - 财政年份:2005
- 资助金额:
$ 12.85万 - 项目类别:
Deterministic Radiotherapy Dose Calculation Method
确定性放疗剂量计算方法
- 批准号:
7325320 - 财政年份:2003
- 资助金额:
$ 12.85万 - 项目类别:
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