Deterministic Radiotherapy Dose Calculation Method

确定性放疗剂量计算方法

• 批准号: 6883471
• 负责人: TODD A WAREING
• 金额: $ 9.93万
• 依托单位: TRANSPIRE, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6883471
• 关键词: human data; mathematical model; method development; patient care management; patient care planning; patient safety /medical error; radiation therapy dosage

DESCRIPTION (provided by applicant): A present need exists for the development of accurate and efficient dose calculation methods for clinical treatment planning in external beam radiotherapy. Due to recent advances in image guided localization techniques and the development of more precise beam delivery methods such as Intensity Modulated Radiation Therapy (IMRT) and Stereotactic Radiosurgery (SRS), the potential exists to substantially reduce margins and improve dose conformity. However, most dose calculation methods in clinical use today employ approximations that limit their accuracy and scope of use, especially with narrow beams in the presence of heterogeneities. As a result, the adoption of more accurate methods such as Monte Carlo is seen as highly desirable. However, Monte Carlo calculations can be time consuming, limiting their effectiveness for clinical treatment planning. The application of a novel deterministic dose calculation method, which solves the differential form of the governing transport equations for neutral and charged particles is proposed. As indicated in preliminary studies, this approach has the potential to provide accuracy comparable to detailed Monte Carlo simulations with a substantially faster computational speed. The proposed approach incorporates anisotropic element adaptation to efficiently resolve complex anatomical features and sharp solution gradients, which is aided by the use of higher-order discontinuous finite element methods on variably sized tetrahedral elements. In Phase 1, a proof-of-concept process will be developed to quantify performance for patient specific dose calculations. This will be validated with detailed Monte Carlo results for selected treatment plans incorporating bone, air and lung heterogeneities, using both wide and narrow beams. Success will be measured on performance relative to Monte Carlo, defined in terms of combined speed and accuracy. Potential enhancements to further improve efficiency in Phase 2 will be identified, and an estimate of achievable clinical performance will be provided.

描述（由申请人提供）：目前需要开发用于外射束放射治疗临床治疗计划的准确和有效的剂量计算方法。 由于图像引导定位技术的最新进展和更精确射束输送方法（如调强放射治疗（IMRT）和立体定向放射外科（SRS））的发展，存在大幅减少边缘和改善剂量一致性的潜力。 然而，目前临床使用的大多数剂量计算方法采用近似法，这限制了其准确性和使用范围，特别是在存在非均匀性的情况下使用窄射束。 因此，采用更准确的方法，如蒙特卡罗被认为是非常可取的。 然而，蒙特卡罗计算可能是耗时的，限制了其临床治疗计划的有效性。 提出了一种新的确定性剂量计算方法的应用，该方法求解了中性粒子和带电粒子的控制输运方程的微分形式。 如初步研究所示，这种方法有可能提供与详细的Monte Carlo模拟相当的精度，并且计算速度更快。 所提出的方法采用各向异性的元素适应，有效地解决复杂的解剖特征和尖锐的解决方案梯度，这是通过使用高阶不连续有限元方法的辅助下，对不连续的四面体元素。 在第1阶段，将开发概念验证过程，以量化患者特定剂量计算的性能。 这将通过选定治疗计划的详细蒙特卡罗结果进行验证，该治疗计划包括骨、空气和肺异质性，使用宽束和窄束。 成功将根据相对于Monte Carlo的性能来衡量，该性能根据组合速度和准确性来定义。 将确定进一步提高II期疗效的潜在增强措施，并提供可实现的临床性能估计。

项目成果

Feasibility of a multigroup deterministic solution method for three-dimensional radiotherapy dose calculations.

三维放射治疗剂量计算的多组确定性求解方法的可行性。

• DOI: 10.1016/j.ijrobp.2008.04.057
• 发表时间: 2008
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Vassiliev,OlegN;Wareing,ToddA;Davis,IanM;McGhee,John;Barnett,Douglas;Horton,JohnL;Gifford,Kent;Failla,Gregory;Titt,Uwe;Mourtada,Firas
• 通讯作者: Mourtada,Firas