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ENDOCRINE REGULATION OF MATERNAL BEHAVIOR

母亲行为的内分泌调节

基本信息

批准号：
7933507
负责人：
ROBERT STAFFORD BRIDGES
金额：
$ 14.14万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2011-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7933507
关键词：
Accounting Address Adult Affect Aftercare Animals Behavior Behavioral Biochemical Biological Birth Brain Caring Computer Systems Development Data Dependence Development Endocrine Endocrine system Estradiol Event Exposure to Female Fostering Goals Hormonal Hormones Infusion procedures Investigation Kidney Knockout Mice Lactation Maintenance Mammals Maternal Behavior Measures Mediating Modeling Mothers Neurobiology Neuronal Plasticity Opioid Physiological Pituitary Gland Placental Lactogen Play Postpartum Period Pregnancy Preparation Primates Process Progesterone Prolactin Prolactin Receptor Rattus Regulation Relative (related person)Reproductive History Research Role Series Site Staging System Testing Time Up-Regulation base experience mRNA Expression maternal aggression neurochemistry novel prevent programs pup relating to nervous system reproductive reproductive function research study social

项目摘要

The long-term goal of this project is to identify the neural and neurochemical mechanisms underlying the regulation of maternal behavior and to elucidate potentially novel mechanisms of neural plasticity associated with the expression of maternal behavior in the adult mammal. The specific hypothesis that will be tested is that the induction, maintenance, and retention of maternal care are under endocrine regulation by a neural lactogenic system, a system that displays significant plasticity as a function of reproductive experience. The first series of studies will examine the role of the neural prolactin (PRL) receptor in the initiation of maternal behavior. Using a rat model, we will determine whether placental lactogens, like PRL, act via the PRL receptor to stimulate the onset of behavior. A second study will use the novel PRL receptor antagonist, S179D-PRL, which will be administered centrally to test the hypothesis that activation of the PRL receptor by lactogenic hormones around the time of birth is essential for the normal onset of maternal care. The third study using ISHH will measure how pregnancy concentrations of progesterone (P) and estradiol affect expression of mRNA for neural PRL receptors. Then, central sites of P action will be examined to see how P affects the onset of maternal care and to delineate a mechanism of P's action in the initiation of maternal behavior. A second series of experiments will determine the involvement of the endocrine system in ongoing maternal care. First, the effects of exposure to PRL-secreting ectopic pituitary grafts on pup- directed maternal care and maternal aggression will be measured. Then, the effects of central administration of the PRL receptor antagonist, S179D-PRL, will be examined in lactating rats. The third set of experiments will delineate the role of the endocrine system in the retention of maternal behavior. The involvement of PRL in the opioid-mediated establishment of the retention of maternal behavior will be assessed. Finally, the effects of prior maternal experience on activation of the neural lactogenic system will be measured to see whether prior maternal experience up-regulates the brain PRL system and makes the female more sensitive to her own neural hormones. The results of these investigations will delineate common endocrine and neurochemical regulators of maternal care in mammals, present a new model for examining neuroplasticity in the adult female, and provide a basis for evaluating the effects of endocrine and neurochemical imbalances on mother-young interactions.

该项目的长期目标是确定神经和神经化学机制的基础上，调节母体行为，并阐明与母体行为相关的神经可塑性的潜在新机制。成年哺乳动物母性行为的表现。将要检验的具体假设是，维持和保留产妇护理是在神经催乳系统，一个系统的内分泌调节在生殖经验的作用下表现出显著的可塑性。第一个系列的研究将审查神经催乳素（PRL）受体在母性行为启动中的作用。使用大鼠模型，我们将确定是否胎盘催乳素，如催乳素，通过催乳素受体的作用，以刺激行为的开始。一第二项研究将使用新的PRL受体拮抗剂S179 D-PRL，将集中给药，以检测假设泌乳素受体在出生时被催乳激素激活，产妇护理的正常开始。使用ISHH的第三项研究将测量怀孕期间孕酮（P）和雌二醇影响神经PRL受体的mRNA表达。然后，P作用的中心位点将审查，看看P如何影响产妇护理的发病，并描绘了P的行动机制，在母性行为的开始。第二个系列的实验将确定内分泌的参与，持续的产妇护理系统。首先，暴露于分泌PRL的异位垂体移植物对幼鼠的影响，将对直接的产妇护理和产妇攻击行为进行衡量。然后，分析了中央行政对地方政府的影响，将在泌乳大鼠中检查PRL受体拮抗剂S179 D-PRL。第三组实验将描述内分泌系统在保持母性行为中的作用。PRL参与阿片介导的将评估母性行为保留的建立。最后，先前的母亲经验的影响将测量神经催乳系统的激活，以观察先前的母亲经历是否上调大脑催乳素系统，使女性对自己的神经激素更敏感。的结果予以调查将描述哺乳动物中母亲护理的常见内分泌和神经化学调节剂，为研究成年女性的神经可塑性提供了一种新的模型，并为评估内分泌和神经化学失衡对母婴互动的影响。