Audiological and Genetic Resource for Pediatric Hearing Research

项目总结： 这个应用程序的总体目标是开发一个集成的生物医学计算基础设施 整合听力学、耳科和遗传学患者数据，以满足研究人员的需求 以病人为中心的儿科听力研究。作为美国最大的儿科保健网络， 费城儿童医院(CHOP)处于独特的地位，可以开发一种计算机 通过对儿科患者进行筛查和综合评估而获得的患者数据的基础设施 有先天性、早发性、进行性和后天性形式的听力损失。在第一阶段， 应用程序(R21)，构建生物医学计算基础设施所需的总体方法将是 下定决心。随后，对包含有限关键数据集的数据库进行概念验证查询 将演示CHOP现有的听力学和遗传学数据库中的数据。在第二阶段(R33) 在应用程序中，我们将扩展数据库，以纳入生物医学特征数据和基因 从一个大的患者队列中获取材料，并开发一个基于Web的界面，用于对数据库进行科学查询 以确保患者信息的匿名性的方式。

Project Summary: The overall objective of this application is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing research. As the largest pediatric health-care network in the United States, the Children's Hospital of Philadelphia (CHOP) is uniquely positioned to develop a computational infrastructure for patient data acquired through screening and comprehensive evaluation of pediatric patients with congenital, early-onset, progressive and acquired forms of hearing loss. In the first phase of the application (R21), the overall approach required for building a biomedical-computing infrastructure will be determined. Subsequently, a proof-of-concept query of the database containing a limited critical set of data from existing audiologic and genetic databases at CHOP will be demonstrated. In the second (R33) phase of the application, we will expand the database to incorporate biomedical characteristics data and genetic material from a large patient cohort, and develop a web-based interface for scientific inquiry of the database in a manner that ensures anonymity of patient information.