A New Model for Eye Disease

眼部疾病的新模型

• 批准号: 7848688
• 负责人: WEN L SENG
• 金额: $ 2.46万
• 依托单位: PHYLONIX PHARMACEUTICALS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-01 至 2009-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848688
• 关键词: Adult; Age related macular degeneration; Animal Model; Antibodies; Biological Assay; Blindness; Blood Vessels; Clinical Treatment; Clinical Trials; Cornea; Corneal Neovascularization; Diabetic Retinopathy; Disease; Extravasation; Eye; Eye diseases; Gene Targeting; Genes; Infection; Injection of therapeutic agent; Injury; Knockout Mice; Libraries; Modeling; Mus; Newborn Infant; Operative Surgical Procedures; Oxygen; Pharmaceutical Preparations; Phase; Phase I Clinical Trials; Phenotype; Preclinical Drug Evaluation; Premature Infant; Process; Research; Retina; Retinal Detachment; Retinopathy of Prematurity; Screening procedure; Staining method; Stains; Supplementation; Therapeutic; Vascularization; Vision; Zebrafish; improved; knock-down; neovascularization; novel therapeutics; ocular neovascularization; postnatal

DESCRIPTION (provided by applicant): Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are the two leading causes of blindness in adults in the industrialized world. Both conditions involve vascular abnormalities, proliferation and leakage of new blood vessels. Retinopathy of prematurity (ROP) is a major cause of newborn blindness in premature infants maintained by oxygen supplementation during the postnatal period. This disease involves intense neovascularization of the retina and leads to retinal detachment. Another cause of blindness is corneal neovascularization, which often results from injury and infection in the cornea. Current mammalian models for ocular neovascularization require lengthy, tedious surgical manipulation and do not always result in improved vision; an alternative rapid, less invasive animal model for studying the process of ocular neovascularization and assessing drug effects will facilitate identification of new therapeutics. Phase I research validated zebrafish as a model for vascularization of the eye. Phase II research will develop a zebrafish model for ocular vascularization that can be used to screen drugs that would be effective in treating debilitating diseases involving neovascularization.

描述（由申请人提供）：糖尿病视网膜病变（DR）和年龄相关性黄斑变性（AMD）是工业化国家成年人失明的两个主要原因。这两种情况都涉及血管异常、新血管增殖和渗漏。早产儿视网膜病变（ROP）是产后靠吸氧维持的早产儿新生儿失明的主要原因。这种疾病涉及视网膜的强烈新生血管形成并导致视网膜脱离。失明的另一个原因是角膜新生血管形成，这通常是由角膜损伤和感染引起的。目前用于眼部新生血管形成的哺乳动物模型需要漫长、繁琐的手术操作，并且并不总能改善视力；另一种用于研究眼部新生血管形成过程和评估药物效果的快速、侵入性较小的动物模型将有助于新疗法的鉴定。第一阶段研究验证了斑马鱼作为眼睛血管化的模型。第二阶段研究将开发一种用于眼部血管形成的斑马鱼模型，该模型可用于筛选可有效治疗涉及新生血管形成的衰弱性疾病的药物。