Effect of kisspeptin on reproductive function in women with hypothalamic amenorrhea

Kisspeptin对下丘脑性闭经女性生殖功能的影响

• 批准号: G0701679/1
• 负责人: Stephen Bloom
• 金额: $ 19.11万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701679%2F1
• 关键词: Effect; kisspeptin; reproductive; function; women

Amennorhea is the term used describe women who have no periods and this results in infertility. In many women the cause of the problem is due to a problem in a part of the brain called the hypothalamus and this is termed hypothalamic amenorrhea. The cause of hypothalamic amenorrhea is not known and treatments are associated with significant side effects. Recent evidence in rodents suggests that a new hormone called kisspeptin may be the missing factor in women with hypothalamic amenorrhea. Administration of kisspeptin to rodents with hypothalamic amenorrhea resulted in an increase in restoration of normal periods and fertility. Women with hypothalamic amenorrhea are infertile and have increased risk of osteoporosis and fractures, which is associated with increased illness and earlier death. The inability to have children is often devastating, and can result in severe depression which can lead to marital breakdown.Investigators in the Department of Metabolic Medicine at Imperial College London will be carrying out the research in this application. They have considerable experience of human infusion studies in order to investigate the physiology of novel hormones and peptides and have developed protocols that ensure reliable, safe delivery of a dose of peptide into humans. The investigators have recently completed the first human infusion studies of kisspeptin in males and females and shown that it stimulates reproductive hormone secretion. The investigators now intend to conduct a study to chronically administer subcutaneous kisspeptin to women with hypothalamic amenorrhea and investigate whether this can restore circulating reproductive hormones and restore their periods and fertility.

Amenorhea是用于描述没有月经的女性的术语，这导致不孕症。在许多妇女的问题的原因是由于一个问题，在一个部分的大脑称为下丘脑，这是所谓的下丘脑闭经。下丘脑性闭经的原因尚不清楚，治疗与显着的副作用有关。最近在啮齿类动物中的证据表明，一种名为kisspeptin的新激素可能是下丘脑性闭经女性的缺失因素。给患有下丘脑性闭经的啮齿类动物施用kisspeptin导致恢复正常月经和生育能力的增加。患有下丘脑性闭经的女性不育，骨质疏松和骨折的风险增加，这与疾病增加和早期死亡有关。不能生育往往是毁灭性的，并可能导致严重的抑郁症，这可能导致婚姻破裂。伦敦帝国理工学院代谢医学系的研究人员将在此应用中进行研究。他们在人体输注研究方面拥有丰富的经验，以研究新型激素和肽的生理学，并开发了确保将一定剂量的肽可靠、安全地输送到人体的方案。研究人员最近完成了对男性和女性的kisspeptin的首次人体输注研究，并表明它刺激生殖激素分泌。研究人员现在打算进行一项研究，长期皮下注射kisspeptin治疗下丘脑性闭经的妇女，并研究这是否可以恢复循环生殖激素，恢复她们的月经和生育能力。