Treatment of obesity by long acting analogues of peptide YY (PYY)

肽 YY (PYY) 的长效类似物治疗肥胖

• 批准号: G0802390/1
• 负责人: Stephen Bloom
• 金额: $ 93.76万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802390%2F1
• 关键词: Treatment; obesity; long; acting; analogues

Obesity is a major cause of illness and death across the world and kills 80 people per day in the UK alone. At present, there is no safe and effective treatment for this disease. Gut bypass surgery does cause major weight loss but can be quite dangerous and has many side effects. Therefore, there is a need for a treatment that can mimic the effects of surgery without the dangerous surgery itself. In response to eating a meal the gut releases appetite inhibiting chemicals, known as gut hormones, which is why after eating you don?t feel hungry any more. These hormones influence parts of the brain to reduce appetite and so limit the amount of food we eat. It is thought that the bypass surgery works by causing an increased release of the satiety gut hormones, chronically reducing ones appetite and the intake of food. In this project, we are testing a modified version of the major satiety gut hormone, known as PYY, that we have successfully developed so that it lasts all day. We wish to show that it is effective at reducing weight, is easy to administer and doesn?t have unexpected side effects. We will also standardise its manufacture and develop a method to measure it accurately in man. At the end of the project we will use this information to get permission to test it in human volunteers, as a novel and potentially exciting treatment for obesity.

肥胖是世界各地疾病和死亡的主要原因，仅在英国每天就有80人死亡。目前，对于这种疾病还没有安全有效的治疗方法。肠道搭桥手术确实会导致体重减轻，但可能相当危险，并有许多副作用。因此，需要一种可以模拟手术效果而不需要危险的手术本身的治疗方法。作为对进食的反应，肠道会释放抑制食欲的化学物质，称为肠道激素，这就是为什么在进食后你不吃东西的原因。I don’我再也不觉得饿了。这些激素会影响大脑的某些部分，从而降低食欲，从而限制我们吃的食物量。据认为，搭桥手术的工作原理是增加饱腹感肠道激素的释放，长期减少食欲和食物的摄入量。在这个项目中，我们正在测试一种主要饱腹感肠道激素的改良版本，称为PYY，我们已经成功开发了这种激素，使其持续一整天。我们希望表明，它是有效的减肥，易于管理，不？不会有意想不到的副作用。我们还将开发一种方法来精确地测量它在人体中的含量。在项目结束时，我们将利用这些信息获得许可，在人类志愿者中进行测试，作为一种新的和潜在的令人兴奋的肥胖治疗方法。