Directional guidance of neural outgrowth using topography and surface chemistry

点击翻译按钮获取中文摘要

Clinical remedies for disorders involving neuronal damage and death that accompany stroke and trauma are not currently available. To develop treatments for these, the ability to control of neurons on surfaces and an understanding of the processes involved is imperative. We are exploring the use of techniques borrowed from the microelectronics industry to make shaped surfaces which we hope, in combination with controlled surface chemistry, will encourage neurons to grow in straight lines and form connections. It is hoped that this will provide useful information on regeneration processes and may in the future even be developed into a therapy to help peripheral nerve regeneration.