Yeast Chromosome Structure, Replication and Segregation

酵母染色体结构、复制和分离

• 批准号: 7771628
• 负责人: David Paul Toczyski
• 金额: $ 0.65万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7771628
• 关键词: Aging; Area; Biochemical; Biological; California; Cell Cycle; Cells; Chromatin; Chromosome Segregation; Chromosome Structures; Chromosomes; Congenital Abnormality; DNA Damage; DNA Double Strand Break; DNA biosynthesis; Double Strand Break Repair; Fission Yeast; Genetic; Genome; Genomics; Health; Human; Human Biology; Kinetochores; Malignant Neoplasms; Mammalian Cell; Mitotic spindle; Molecular; Nuclear; Pathway interactions; Proteins; Research; Research Personnel; Role; Series; Structure; Students; Technology; Telomere Maintenance; Time; Work; Yeasts; abstracting; chromosome replication; histone modification; insight; meetings; novel; posters; protein degradation; response; segregation; symposium; tool

DESCRIPTION (provided by applicant): The 9th Yeast Chromosome Structure, Replication, and Segregation Conference sponsored by FASEB will be held on 24-29 June, 2006 at Indian Wells, California, and thereafter in 2008 (10th Conference) and 2010 (11th Conference). The Conference will provide up to 250 places for students, postdocs, and senior investigators to meet and discuss novel findings of the past year. This conference is the latest iteration in a highly successful series that uniquely combines researchers investigating different aspects of chromosome function. As in the past, invited speakers will present their most recent work, with some talks chosen from the abstracts. In addition, there is ample time for discussion and poster presentations. Research into yeast chromosome structure, and the mechanisms and control of chromosome replication and segregation, continues at a rapid pace and underpins related research in mammalian cells. Recent advances provide new insights into nuclear organization, the role of histone modification in chromatin silencing and DNA damage response, the control of DNA replication, the role of protein degradation in cell cycle transitions in general and chromosome segregation in particular, the molecular pathways of checkpoint responses, kinetochore structure and function, the connection between telomere maintenance and DNA double stranded break repair, and the assembly and function of the mitotic spindle. Because of the powerful combination of biochemical, cell biological, and genetic tools, as well as more recently genomic technologies now at the disposal of yeast researchers, studies in budding and fission yeasts have led the field in many of these areas. Most of the proteins and mechanisms employed by yeast cells are conserved in human cells, making this work directly relevant to human biology. Indeed, chromosome function and genome integrity are fundamental to many aspects of human health, and are directly implicated in cancer, aging, and birth defects. All of these are characterized by disruptions in normal chromosome function, which can be readily studied in yeast.

简介（由申请人提供）：由FASEB主办的第九届酵母染色体结构、复制和分离会议将于2006年6月24日至29日在加利福尼亚州印第安维尔斯举行，此后将于2008年（第10届会议）和2010年（第11届会议）举行。会议将为学生、博士后和高级研究人员提供多达250个名额，以会面和讨论过去一年的新发现。这次会议是一个非常成功的系列的最新迭代，该系列独特地结合了研究染色体功能不同方面的研究人员。和过去一样，受邀的演讲者将介绍他们最近的工作，其中一些演讲选自摘要。此外，有充足的时间进行讨论和海报展示。