BREAST DENSITY BY DXA

通过 DXA 测定乳房密度

• 批准号: 7960432
• 负责人: GERTRAUD MASKARINEC
• 金额: $ 1.42万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960432
• 关键词: 16 year old; Adolescent; Adult; Age Distribution; Age-Years; Asian Americans; Biological; Body Weight; Breast; Breast Cancer Risk Factor; Caucasians; Caucasoid Race; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Daughter; Development; Dual-Energy X-Ray Absorptiometry; Eligibility Determination; Enrollment; Female Adolescents; Funding; Genetic; Gonadal Steroid Hormones; Grant; Hawaii; Hormones; Image; Institution; Internal Breast Prosthesis; Life; Malignant Neoplasms; Mammographic Density; Mammography; Measures; Methods; Monitor; Morbid Obesity; Mothers; Oral Contraceptives; Pacific Island Americans; Paralysed; Pharmaceutical Preparations; Radiation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Risk; Roentgen Rays; Scanning; Selective Estrogen Receptor Modulators; Source; Staging; United States National Institutes of Health; Woman; base; breast density; cancer risk; girls; malignant breast neoplasm; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increasing epidemiologic and experimental evidence provides compelling evidence that breast cancer risk is determined early in life. A method to monitor breast development and composition in young women and girls is currently not available because of the risk of X-ray based mammograms. Dual Energy X-ray Absorptiometry (DXA) has extremely low radiation and is commonly available. The underlying rationale of this project is that predictors of breast cancer risk may be observed during pubertal development in girls. The specific aims of this project among adult women and adolescent girls, who will be recruited as mothers and biological daughter, will be to: - Correlate breast density measured by DXA with mammographic density among adult women; - Compare the association of known breast cancer risk factors with breast density from DXA scans to their association with mammographic density; - Assess DXA breast density and Tanner stage of breast maturation among adolescent girls; - Relate DXA breast density to other observable measure of pubertal maturation; - Examine the relation between breast density measured by DXA in mothers and biological daughters Our hypotheses are as follows: 1. DXA imaging can provide a valid assessment of breast density in adult women and in young girls; 2. DXA assessed breast density is associated with indicators of pubertal maturation and with known breast cancer risk factors; and 3. Due to its strong genetic component, breast density obtained from the DXA scans is correlated between mothers and biological adolescent daughters. Women at least 40 years of age with biological daughters 10-16 years of age will be recruited from Kaiser Permanente Hawaii. Expected enrollment is 50 Caucasian and 50 Asian-American or Pacific Islander pairs. The eligibility criteria are: 1. Normal mammogram during recent 6 months for adult women; 2. Biological daughters willing to participate in Tanner staging; 3. No condition that would interfere with study participation (e.g. cancer, paralysis, morbid obesity, breast implants); 4. Mother and daughter not taking medications that may interfere with hormone levels: oral contraceptives, other sex hormones, SERMs; 5. Willing to obtain DXA scans. We will calculate summary statistics to describe the distribution of age, body weight, pubertal stages, DXA measures, and mammographic density.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 越来越多的流行病学和实验证据提供了令人信服的证据，证明乳腺癌风险是在生命早期确定的。 由于基于 X 射线的乳房 X 光检查存在风险，目前尚无监测年轻女性和女孩乳房发育和成分的方法。 双能 X 射线吸收测定法 (DXA) 的辐射极低，并且很常见。该项目的基本原理是，在女孩青春期发育期间可以观察到乳腺癌风险的预测因素。 该项目针对将被招募为母亲和亲生女儿的成年妇女和少女的具体目标是： - 将 DXA 测量的乳腺密度与成年女性的乳房 X 光密度相关联； - 比较已知乳腺癌危险因素与 DXA 扫描乳腺密度的关联以及它们与乳房 X 光密度的关联； - 评估青春期女孩的 DXA 乳房密度和乳房成熟的 Tanner 阶段； - 将 DXA 乳房密度与青春期成熟的其他可观察指标联系起来； - 检查母亲和亲生女儿通过 DXA 测量的乳腺密度之间的关系 我们的假设如下： 1. DXA 成像可以对成年女性和年轻女孩的乳腺密度提供有效的评估； 2. DXA 评估的乳腺密度与青春期成熟指标和已知的乳腺癌危险因素相关； 3. 由于其强大的遗传成分，从 DXA 扫描获得的乳腺密度在母亲和青春期女儿之间具有相关性。 将从 Kaiser Permanente Hawaii 招募年满 40 岁且亲生女儿 10-16 岁的女性。 预计入学人数为 50 对白人和 50 对亚裔美国人或太平洋岛民。 资格标准为： 1. 成年女性近6个月内乳房X线检查正常； 2.亲生女儿愿意参加Tanner分期； 3. 没有影响参与研究的疾病（例如癌症、瘫痪、病态肥胖、乳房植入物）； 4. 母亲 女儿未服用可能干扰激素水平的药物：口服避孕药、其他性激素、SERM； 5.愿意获得DXA扫描。 我们将计算汇总统计数据来描述年龄、体重、青春期阶段、DXA 测量和乳房 X 光密度的分布。