BREAST DENSITY BY DXA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 越来越多的流行病学和实验证据提供了令人信服的证据，表明乳腺癌风险是在生命早期确定的。由于X光乳房X光检查的风险，目前还没有一种方法来监测年轻妇女和女孩的乳房发育和组成。双能X射线吸收法(DXA)具有极低的辐射，而且很常见。该项目的基本原理是，可以在女孩的青春期发育期间观察到乳腺癌风险的预测因素。 这一项目在成年妇女和少女中的具体目标将是： -将DXA测量的乳房密度与成年女性的乳房X光照相密度相关； -比较已知的乳腺癌危险因素与DXA扫描的乳房密度之间的关系，以及它们与乳房X光照相密度之间的关系； -评估DXA乳房密度和青春期女孩乳房成熟的晒黑阶段； -将DXA乳房密度与青春期成熟的其他可观察指标联系起来； -检查DXA测量的母亲和亲生女儿的乳房密度之间的关系 我们的假设如下：1.DXA成像可以有效地评估成年女性和年轻女孩的乳房密度；2.DXA评估的乳房密度与青春期成熟指标和已知的乳腺癌风险因素有关；3.由于其强大的遗传成分，从DXA扫描获得的乳房密度在母亲和青春期亲生女儿之间存在相关性。 夏威夷Kaiser Permanente将招募年龄至少40岁、有亲生女儿10-16岁的女性。预计将有50对高加索人和50对亚裔美国人或太平洋岛民参加。符合资格的标准是：1.成年妇女最近6个月内的乳房X光检查正常；2.愿意参加Tanner分期的亲生女儿；3.没有影响学习的情况(如癌症、瘫痪、病态肥胖、隆胸)；4.母亲 和女儿不服用可能干扰激素水平的药物：口服避孕药、其他性激素、SERM；5.愿意接受DXA扫描。 我们将计算汇总统计数据来描述年龄、体重、青春期阶段、DXA测量和乳房X光检查密度的分布。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increasing epidemiologic and experimental evidence provides compelling evidence that breast cancer risk is determined early in life. A method to monitor breast development and composition in young women and girls is currently not available because of the risk of X-ray based mammograms. Dual Energy X-ray Absorptiometry (DXA) has extremely low radiation and is commonly available. The underlying rationale of this project is that predictors of breast cancer risk may be observed during pubertal development in girls. The specific aims of this project among adult women and adolescent girls, who will be recruited as mothers and biological daughter, will be to: - Correlate breast density measured by DXA with mammographic density among adult women; - Compare the association of known breast cancer risk factors with breast density from DXA scans to their association with mammographic density; - Assess DXA breast density and Tanner stage of breast maturation among adolescent girls; - Relate DXA breast density to other observable measure of pubertal maturation; - Examine the relation between breast density measured by DXA in mothers and biological daughters Our hypotheses are as follows: 1. DXA imaging can provide a valid assessment of breast density in adult women and in young girls; 2. DXA assessed breast density is associated with indicators of pubertal maturation and with known breast cancer risk factors; and 3. Due to its strong genetic component, breast density obtained from the DXA scans is correlated between mothers and biological adolescent daughters. Women at least 40 years of age with biological daughters 10-16 years of age will be recruited from Kaiser Permanente Hawaii. Expected enrollment is 50 Caucasian and 50 Asian-American or Pacific Islander pairs. The eligibility criteria are: 1. Normal mammogram during recent 6 months for adult women; 2. Biological daughters willing to participate in Tanner staging; 3. No condition that would interfere with study participation (e.g. cancer, paralysis, morbid obesity, breast implants); 4. Mother and daughter not taking medications that may interfere with hormone levels: oral contraceptives, other sex hormones, SERMs; 5. Willing to obtain DXA scans. We will calculate summary statistics to describe the distribution of age, body weight, pubertal stages, DXA measures, and mammographic density.