BREAST DENSITY BY DXA

通过 DXA 测定乳房密度

• 批准号: 7725330
• 负责人: GERTRAUD MASKARINEC
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7725330
• 关键词: Adolescent; Adult; Age Distribution; Age-Years; Asian Americans; Biological; Body Weight; Breast; Breast Cancer Risk Factor; Caucasians; Caucasoid Race; Computer Retrieval of Information on Scientific Projects Database; Condition; Daughter; Development; Dual-Energy X-Ray Absorptiometry; Eligibility Determination; Enrollment; Female Adolescents; Funding; Genetic; Gonadal Steroid Hormones; Grant; Hawaii; Hormones; Image; Institution; Internal Breast Prosthesis; Life; Malignant Neoplasms; Mammographic Density; Mammography; Measures; Methods; Monitor; Morbid Obesity; Mothers; Oral Contraceptives; Pacific Island Americans; Paralysed; Pharmaceutical Preparations; Radiation; Recruitment Activity; Research; Research Personnel; Resources; Risk; Roentgen Rays; Scanning; Selective Estrogen Receptor Modulators; Source; Staging; United States National Institutes of Health; Woman; base; breast density; cancer risk; girls; malignant breast neoplasm; statistics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increasing epidemiologic and experimental evidence provides compelling evidence that breast cancer risk is determined early in life. A method to monitor breast development and composition in young women and girls is currently not available because of the risk of X-ray based mammograms. Dual Energy X-ray Absorptiometry (DXA) has extremely low radiation and is commonly available. The underlying rationale of this project is that predictors of breast cancer risk may be observed during pubertal development in girls. The specific aims of this project among adult women and adolescent girls, who will be recruited as mothers and biological daughter, will be to: - Correlate breast density measured by DXA with mammographic density among adult women; - Compare the association of known breast cancer risk factors with breast density from DXA scans to their association with mammographic density; - Assess DXA breast density and Tanner stage of breast maturation among adolescent girls; - Relate DXA breast density to other observable measure of pubertal maturation; - Examine the relation between breast density measured by DXA in mothers and biological daughters Our hypotheses are as follows: 1. DXA imaging can provide a valid assessment of breast density in adult women and in young girls; 2. DXA assessed breast density is associated with indicators of pubertal maturation and with known breast cancer risk factors; and 3. Due to its strong genetic component, breast density obtained from the DXA scans is correlated between mothers and biological adolescent daughters. Women at least 40 years of age with biological daughters 10-16 years of age will be recruited from Kaiser Permanente Hawaii. Expected enrollment is 50 Caucasian and 50 Asian-American or Pacific Islander pairs. The eligibility criteria are: 1. Normal mammogram during recent 6 months for adult women; 2. Biological daughters willing to participate in Tanner staging; 3. No condition that would interfere with study participation (e.g. cancer, paralysis, morbid obesity, breast implants); 4. Mother and daughter not taking medications that may interfere with hormone levels: oral contraceptives, other sex hormones, SERMs; 5. Willing to obtain DXA scans. We will calculate summary statistics to describe the distribution of age, body weight, pubertal stages, DXA measures, and mammographic density.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 越来越多的流行病学和实验证据提供了令人信服的证据，表明乳腺癌的风险是在生命早期确定的。 由于X光乳房X光检查的风险，目前还没有监测年轻妇女和女孩乳房发育和组成的方法。 双能X射线吸收测定法（DXA）具有极低的辐射，并且通常可用。该项目的基本原理是，乳腺癌风险的预测因素可以在女孩的青春期发育期间观察到。 该项目针对成年妇女和少女（将被招募为母亲和亲生女儿）的具体目标是： - 成年女性DXA测量乳腺密度与钼靶摄影密度的相关性研究 - 比较已知的乳腺癌危险因素与DXA扫描乳腺密度的相关性及其与乳房X线摄影密度的相关性; - 评估青春期少女的DXA乳腺密度和乳房成熟的坦纳分期; - 将DXA乳腺密度与其他可观察到的青春期成熟度测量相关联; - DXA乳腺密度测量值与亲生女儿的关系探讨 我们的假设如下：1. DXA成像可以有效评估成年女性和年轻女孩的乳腺密度; 2. DXA评估的乳腺密度与青春期成熟的指标和已知的乳腺癌风险因素相关; 3.由于其强大的遗传成分，从DXA扫描获得的乳房密度与母亲和生物青春期女儿之间存在相关性。 将从夏威夷Kaiser Permanente招募至少40岁、有10-16岁亲生女儿的妇女。 预计入组人数为50对高加索人和50对亚裔美国人或太平洋岛民。 资格标准是：1。成年女性近6个月乳房X线检查正常; 2.亲生女儿愿意参加坦纳分期; 3.没有可能干扰研究参与的疾病（例如癌症、瘫痪、病态肥胖、乳房植入体）; 4.母亲 和女儿没有服用可能干扰激素水平的药物：口服避孕药，其他性激素，SERM; 5.愿意获得DXA扫描。 我们将计算汇总统计量，以描述年龄、体重、青春期阶段、DXA测量和乳腺摄影密度的分布。