METABOLIC SYNDROME

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这是一项以社区为基础的关于超重夏威夷土著(NH)和萨摩亚儿童代谢综合征(MS)发展的观察性研究。这项研究将以夏威夷的瓦胡岛为基础，以两个卫生中心为基础，这两个卫生中心为NH和萨摩亚患者提供高比例的Waianae海岸综合卫生中心(WCCHC)和Kokua Kalihi Valley卫生中心(KKV)。受试者将从瓦胡岛的健康中心、健康中心附近的社区团体和临床医生中招募。我们将研究两组患代谢综合征的高危儿童：夏威夷原住民和萨摩亚人。 +夏威夷原住民肥胖症和糖尿病的患病率最高，寿命最短，主要是由于心血管疾病、中风和糖尿病。 +萨摩亚人来自萨摩亚的波利尼西亚群岛，身材魁梧，与给定的BMI相比，肌肉质量更大。肥胖率，包括严重肥胖症(身体质量指数或BMI 40)是世界上最高的之一。 具体目标：1)确定超重的高危人群以及超重的夏威夷土著和萨摩亚青年的“高危”人群中代谢综合征的患病率。2)在儿童高危人群中检查与代谢综合征相关的生理和实验室标志物的模式。3)探讨妊娠期糖尿病、出生体重、出生后3年生长速度与多发性硬化症的关系 设计：从瓦胡岛的卫生中心、社区团体和临床医生招募的高危儿童进行基于社区的研究。 预测变量包括性别、种族、BMI、腰围、出生体重和身长、母亲糖尿病、母亲肥胖、母乳喂养和儿童早期的“快速成长”。 结果变量包括BMI、血压、胰岛素抵抗(计算)、高密度脂蛋白、甘油三酯、血清胆固醇、SGPT、SGOT。 儿童研究中心的人员将参与提交IRB，协助提交同意书和数据收集表格，协调研究，协助研究程序，并利用儿童权利委员会实验室进行标本存储、数据收集、数据库开发和数据分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a community-based observational study on development of metabolic syndrome (MS) in overweight Native Hawaiian (NH) and Samoan children. The study will be based on the island of Oahu in Hawaii and based at two health centers that serve a high proportion of NH and Samoan patients  Waianae Coast Comprehensive Health Center (WCCHC) and Kokua Kalihi Valley Health Center (KKV). Subjects will be recruited from health centers, community groups near the health centers and clinicians on Oahu. We will study two groups of children at high risk for developing metabolic syndrome: Native Hawaiians and Samoans. + Native Hawaiians have the highest prevalence of obesity and diabetes and the shortest life spans in Hawaii, primarily due to cardiovascular disease, stroke and diabetes. + Samoans, originally from the Polynesian islands of Samoa, are large framed and have a larger muscle mass for a given BMI. The prevalence of obesity, including severe obesity (Body Mass Index or BMI 40) is among the highest in the world. Specific Aims: 1) To determine the prevalence of metabolic syndrome in a high-risk population of overweight and "at-risk" for overweight Native Hawaiian and Samoan youth. 2) To examine the pattern of physical and laboratory markers associated with metabolic syndrome in a high-risk population of children. 3) To examine the relationship between maternal gestational diabetes, birth weight, and growth rate in the first 3 years of life with the development of MS Design: Community-based research study in at-risk children recruited from health centers, community groups and clinicians on Oahu. Predictor variables include gender, ethnicity, BMI, waist circumference, birth weight and length, maternal diabetes, maternal obesity, breastfeeding and "rapid growth" in early childhood. Outcome variables include BMI, blood pressure, insulin resistance (calculated), HDL, triglycerides, serum cholesterol, SGPT, SGOT. CRC personnel will be involved in IRB submission, assistance with consent and data collection forms, coordinating the study, assistance with study procedures, and use of CRC lab for specimen storage, data collection, database development, and data analysis.