STIMULATION OF VAGUS NERVE PROVIDES CARDIAC PROTECTION

刺激迷走神经提供心脏保护

• 批准号: 7959618
• 负责人: Yifan Li
• 金额: $ 1.24万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959618
• 关键词: Adaptive Behaviors; Cardiac; Chronic; Computer Retrieval of Information on Scientific Projects Database; Functional disorder; Funding; Goals; Grant; Heart; Institution; Left; Mediating; Muscarinics; Parasympathetic Nervous System; Pilot Projects; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; cholinergic; neuromechanism; protective effect; receptor; vagus nerve stimulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pharmacological stimulation of parasympathetic nervous system cholinergic action provides protective effects against cardiac remodeling and dysfunction. In contrast, lack of cholinergic muscarinic type 2 receptors, the major receptors that mediate control of the heart, results in cardiac dysfunction. A long-term goal of my research is to investigate PSNS cardio protective effects and the underlying mechanisms. The specific aim of this pilot study is to test a hypothesis that chronic left vagus nerve stimulation provides a protection against cardiac remodeling and dysfunction via enhancing PSNS cholinergic action.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 副交感神经系统胆碱能作用的药理学刺激提供了对心脏重塑和功能障碍的保护作用。 相反，缺乏胆碱能毒蕈碱2型受体（介导心脏控制的主要受体）会导致心脏功能障碍。 本研究的一个长期目标是研究PSNS的心脏保护作用及其机制。 这项初步研究的具体目的是检验一个假设，即慢性左迷走神经刺激通过增强PSNS胆碱能作用提供对心脏重塑和功能障碍的保护。