NEUROHUMORAL CONTROL OF CARDIOVASCULAR FUNCTIONS

心血管功能的神经体液控制

• 批准号: 7960318
• 负责人: Yifan Li
• 金额: $ 3.47万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960318
• 关键词: Autonomic Pathways; Biomedical Research; Cardiovascular Diseases; Cardiovascular Physiology; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Endocrine; Funding; Generations; Grant; Heart; Heart failure; Hypothalamic structure; Institution; Laboratory Study; Neurotransmitters; Peripheral; Physiological; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Role; Source; South Dakota; United States National Institutes of Health; cytokine; interest; morphometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dr. Li's laboratory studies neurohumoral control of cardiovascular functions including interactions of neurotransmitters/modulators in central autonomic pathways and central mechanisms involved in altered autonomic functions in cardiovascular diseases including heart failure and diabetes. They also study interactions of neurotransmitters/modulators within the hypothalamus in endocrine regulations and their roles in regulation of cardiovascular functions in physiological and pathophysiological conditions. They are particularly interested in neuroimmunoregulation as it applies to autonomic regulation of cytokine generation and release and their roles in cardiovascular diseases and in central and peripheral actions of cytokines on neuro-endocrine functions and their roles in regulation of cardiovascular functions including the morphometry of normal and diseased hearts.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 李博士的实验室研究心血管功能的神经体液控制，包括中枢自主神经通路中神经递质/调节剂的相互作用，以及参与心血管疾病(包括心力衰竭和糖尿病)自主神经功能改变的中枢机制。他们还研究了下丘脑内神经递质/调节剂在内分泌调节中的相互作用，以及它们在生理和病理生理条件下调节心血管功能中的作用。他们对神经免疫调节特别感兴趣，因为它应用于细胞因子产生和释放的自主调节及其在心血管疾病中的作用，以及细胞因子对神经内分泌功能的中枢和外周作用及其在心血管功能调节中的作用，包括正常和疾病心脏的形态计量学。