Investigating Thymosin beta4-mediated myocardial regeneration and anti-inflammatory wound healing in the injured heart

研究胸腺素β4介导的心肌再生和抗炎伤口愈合的受损心脏

• 批准号: G0701970/1
• 负责人: Paul Riley
• 金额: $ 55.23万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701970%2F1
• 关键词: Investigating; Thymosin; beta4; mediated; myocardial

Coronary artery disease resulting in heart attacks is the number one killer worldwide. Approaches to curing or mitigating the effects of a heart attack have to-date principally involved surgical intervention such as coronary vessel intervention or artery bipass. In the field of biomedical research considerable effort has been invested in the search for adult or embryonic stem cells which may replace damaged cells in a diseased heart or in the identification of key factors (proteins) which may induce resident stem cells within the adult heart to initiate repair. Our studies seek to characterise one such factor, Thymosin beta4 (Tbeta4) in terms of its potential to orchestrate a DIY repair mechanism within the diseased/injured adult heart. We have significant evidence from previous studies that Tbeta4 can promote survival of heart muscle cells in an animal model of human heart attack and that it may also induce new blood vessels (a process called vasculogenesis) to help sustain the surviving healthy cells and facilitate repair of the injured heart. We will now confirm a role for Tbeta4 in initiating regeneration of lost muscle in the adult heart proper and also investigate whether this new muscle growth is accompanied by reduced inflammation and scarring to futher promote wound healing. Tbeta4 is currently in the early stages of phase I clinical trials for treatment of heart attack, the proposed studies therefore, seek to understand the mechanisms underlying how Tbeta4 may act as a regenerative therapy for heart disease.

导致心脏病发作的冠状动脉疾病是全球头号杀手。迄今为止，治疗或减轻心脏病发作影响的方法主要涉及外科手术，如冠状动脉血管介入或动脉双通。在生物医学研究领域，人们投入了相当大的努力来寻找可以替代患病心脏中受损细胞的成体或胚胎干细胞，或者鉴定可以诱导成体心脏中的常驻干细胞启动修复的关键因子（蛋白质）。我们的研究试图阐明一个这样的因素，胸腺素β 4（Tbeta 4）在患病/受伤的成人心脏内协调DIY修复机制的潜力。我们从以前的研究中获得了重要的证据，即Tbeta 4可以促进人类心脏病发作动物模型中心肌细胞的存活，并且它还可以诱导新血管（一种称为血管生成的过程），以帮助维持存活的健康细胞并促进受损心脏的修复。我们现在将确认Tbeta 4在启动成人心脏中丢失肌肉再生中的作用，并研究这种新的肌肉生长是否伴随着炎症和瘢痕形成的减少，以进一步促进伤口愈合。Tbeta 4目前正处于治疗心脏病发作的I期临床试验的早期阶段，因此，拟议的研究旨在了解Tbeta 4如何作为心脏病再生疗法的机制。