3 of 4: Study of Osteoporotic Fractures (SOF)-Pittsburgh Clinical Center

3 of 4：骨质疏松性骨折 (SOF) 研究-匹兹堡临床中心

• 批准号: 7927143
• 负责人: JANE Ann CAULEY
• 金额: $ 14.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7927143
• 关键词: Achievement; Ancillary Study; Archives; Authorship; Baltimore; Biochemical Markers; Biological Assay; Biological Markers; California; Cholecalciferol; Clinical; Cognition; Cognitive; Collection; Creatinine; Data; Data Analyses; Data Collection; Data Set; Development; Doctor of Public Health; Documentation; Elderly woman; Environment; Fracture; Funding; Glomerular Filtration Rate; Hip Fractures; Inflammation; Institution; Interleukin-6; International; Internet; Laboratories; Lead; Life; Lower Extremity; Maintenance; Manuscripts; Maryland; Measurement; Measures; Medical center; Mentors; Minnesota; Paper; Participant; Performance; Physical Function; Physical activity; Play; Principal Investigator; Productivity; Publications; Publishing; Qualifying; Renal function; Request for Proposals; Research; Research Institute; Research Personnel; Resources; Risk; Role; Sampling; San Francisco; Serum; Site; Specific qualifier value; Specimen; Testing; Tumor Necrosis Factor-alpha; United States National Institutes of Health; Universities; Vision; Visit; Vitamin D; Woman; Work; Writing; abstracting; base; clinical research site; cognitive function; cohort; data acquisition; data sharing; fall risk; falls; follow-up; healthy aging; meetings; member; operation; osteoporosis with pathological fracture; post gamma-globulins; prevent; public health relevance; web site; weight maintenance

DESCRIPTION (provided by applicant): This proposal requests support for the investigators in the Clinical Centers in the Study of Osteoporotic Fractures (SOF) to analyze data, publish results, and continue scientific participation in SOF during the 4th and 5th years of our competitively renewed and (partially) funded 5 year study. We are NOT requesting support for collecting data or assaying samples and we have NOT changed any aspect of the funded 5 year study. SOF was renewed in August 2006 to study why some women achieve excellent lower extremity and cognitive function in the 9th and 10th decades of life and why some women have maintained healthy trajectories of lower extremity and cognitive function over 10 years of follow-up. We are specifically testing whether renal function, inflammation, and vitamin D are important to maintaining and achieving high levels of function and lower risks of falls, and hip fractures. Each SOF Clinical Center PI took the lead in developing one of the SOF Aims. NIH funded our Year 20 Exam in which we are measuring cognitive and lower extremity function. We are on target to complete the visits by the end of September, 2008 so that we can begin to select and pull samples and start biomarker assays later in that 3rd year. The bulk of the data will be analyzed and papers produced in the 4th and 5th years of the renewal. Investigators at the Clinical Centers - including young investigators - would do most of that work. The Coordinating Center was funded for 5 years. However, Clinical Centers were funded for only 3 years (8/1/06-7/31/09) just to complete the Exam. The 3 year limit on Clinical Center funding would - inadvertently - prevent the Clinical Center investigators from analyzing and publishing results from the aims they developed. Therefore, we request support for the SOF Clinical Center investigators to analyze and publish results from this funded competitive renewal during the 4th and 5th years of our renewal and continue their essential participation in the scientific activities of SOF. In addition, NIA requested that we include a plan for public data sharing for SOF in this proposal. Our plan builds on our successful public access web portal, SOF Online, and proposes to add downloadable and documented public release data sets to the website to allow external investigators direct access to identified SOF data. PUBLIC HEALTH RELEVANCE: The Study of Osteoporotic Fractures (SOF) was competitively renewed to study why some women achieve and maintain high cognitive and physical function, and low risk of falls and fractures in the 9th and 10th decade of life. The SOF Coordinating Center was funded for 5 years; SOF clinical centers for 3 years. In order to meet these aims, two years of support is requested for the SOF clinical centers.

描述(由申请人提供)：本提案请求支持临床中心研究骨质疏松性骨折(SOF)的研究人员分析数据，公布结果，并在我们竞争性更新和(部分)资助的5年研究的第4和第5年继续参与SOF的科学研究。我们没有要求为收集数据或分析样本提供支持，我们也没有改变这项由基金资助的5年研究的任何方面。Sof于2006年8月更新，以研究为什么一些女性在第9年和第10年的生命中取得了优异的下肢和认知功能，以及为什么一些女性在10年的随访中保持了健康的腿部和认知功能轨迹。我们正在专门测试肾功能、炎症和维生素D对于维持和实现高水平的功能以及降低跌倒和髋部骨折的风险是否重要。每个SOF临床中心PI都带头制定了SOF的一个目标。美国国立卫生研究院资助了我们的第20年考试，在这项考试中，我们测量了认知和腿部功能。我们的目标是在2008年9月底之前完成访问，这样我们就可以开始挑选和提取样本，并在第三年晚些时候开始生物标记物分析。大部分数据将在续订的第4年和第5年进行分析和撰写论文。临床中心的研究人员--包括年轻研究人员--将承担大部分工作。协调中心的资助期限为5年。然而，仅仅为了完成考试，临床中心只资助了3年(8/1/06-7/31/09)。临床中心资金的3年限制将-无意中-阻止临床中心调查人员分析和发布他们制定的目标的结果。因此，我们请求支持SOF临床中心调查人员在我们更新的第4年和第5年期间分析和发布这次资助的竞争更新的结果，并继续他们对SOF科学活动的基本参与。此外，NIA要求我们在本提案中包括SOF的公共数据共享计划。我们的计划建立在我们成功的公共访问门户网站SOF Online的基础上，并提议在网站上增加可下载和有文件记录的公开发布数据集，以允许外部调查人员直接访问已确定的SOF数据。公共卫生相关性：对骨质疏松性骨折(SOF)的研究竞争性地更新，以研究为什么一些女性在第9和第10年实现并保持较高的认知和身体功能，以及较低的跌倒和骨折风险。SOF协调中心资助5年；SOF临床中心资助3年。为了实现这些目标，要求为SOF临床中心提供两年的支持。