ASBMR Three Year Symposia

美国骨与矿物研究学会(ASBMR)是世界上最大的专业、科学和 医学会成立的目的是将临床和实验室科学家聚集在一起，他们参与了 研究骨骼、矿物和肌肉骨骼科学，有成功的举办年度专题讨论会的历史。 自2002年以来，由NIH R13年度拨款资助的会议。2015年，ASBMR获得了为期三年的R13 涵盖2016-2018年的三个会前研讨会。本申请寻求为三年R13赠款提供资金，以 推进肌肉骨骼疾病领域的三个具体科学研究领域 2019、2010和2021年：1)“肌肉：通向新治疗目标的道路”；2)“种子和土壤： 骨癌的治疗目标“；3)”骨骼老化的生物学：对骨折的影响“ 预防“。这三个领域涵盖了一系列共同导致主要临床发病率的主题 残疾和死亡率。本R13的总体目标是刺激进一步的进展，从而导致 通过汇聚每个领域最优秀的研究人员，改善肌肉骨骼疾病的患者护理 将与ASBMR年会同时举行的三个专题讨论会。三个研讨会中的每一个 将回顾每个主题领域的最新进展，与与会者交流想法，并激励 年轻的和成熟的研究人员之间的互动。对于三个研讨会中的每一个，与会者都将 鼓励参加后续的ASBMR年会，以获得更多互动机会 肌肉骨骼研究人员。所有三年的议程都是由一个组委会制定的 头两年有忠实的演讲者和主席。议程包括成熟的和年轻的 调查人员，女性和男性。由于ASBMR大约一半的成员来自美国以外，我们还 包括一些主要的国际演讲者。在每一次会议结束时，都会有一个“共进晚餐”的夜晚。 计划在会议上让年轻的调查人员和更资深的发言者进行直接互动。在……里面 2019年，研讨会将评估新兴的肌肉基础科学(自噬肌肉，线粒体， 干细胞和卫星细胞)，翻译研究，包括开发潜在的治疗靶点和 临床研究。2020年，研讨会的重点将是骨骼贡献的最新进展 微环境对骨癌的病理生理、防治作用。2021年研讨会 将汇聚老年科学和骨骼生物学的专家，以加强我们对生物老化的了解 这是治疗干预的目标，以增加健康寿命并将其应用于老龄化 骷髅。

The American Society for Bone and Mineral Research (ASBMR), the largest professional, scientific and medical society established to bring together clinical and laboratory-based scientists who are involved in the study of bone, mineral and musculoskeletal science, has had a successful history of conducting annual topical meetings funded by single year NIH R13 grants since 2002. In 2015, ASBMR received a three-year R13 to cover three pre-meeting symposia for 2016-2018.This application seeks funding for a three-year R13 grant to advance the field of musculoskeletal diseases by focusing on three specific areas of scientific research in 2019, 2010 and 2021: 1) “Muscle: The Path Forward to New Therapeutic Targets”; 2) “The Seed and Soil: Therapeutic Targets for Cancer in Bone”; 3) “Biology of the Aging Skeleton: Implications for Fracture Prevention”. These three areas cover a range of topics that collectively contribute to major clinical morbidity disability and mortality. The overall objective of this R13 is to stimulate further advances that will result in improved patient care for musculoskeletal diseases by bringing together the best researchers for each of the three symposia that will be held in conjunction with the ASBMR Annual Meetings. Each of the three symposia will review the state of the art in each topic area, exchanging ideas with attendees, and stimulating the interaction between young and established researchers. For each of the three symposia, attendees will be encouraged to attend the subsequent ASBMR Annual Meetings for additional opportunities to interact with musculoskeletal researchers. Agendas for all three years have been developed by an organizing committee with committed speakers and chairs for the first two years. The agendas include established and young investigators, women and men. Since about half of ASBMR membership is from outside the US, we also include a number of key international speakers. At the end of each meeting, a “dine-around” evening is planned to allow direct interaction between young investigators and more senior speakers at the meeting. In 2019, the symposium will appraise the emerging basic science of muscle (autophagy muscle, mitochondria, stem and satellite cells), translational research including development of potential therapeutic targets and to clinical research. In 2020, the symposium will focus on recent advances in the contributions of the bone microenvironment to the pathophysiology, prevention and treatment of cancer in bone. The 2021 symposium will bring together experts in geroscience and skeletal biology to enhance our understanding of biological aging that is being targeted by therapeutic interventions to increase health span and apply them to the aging skeleton.