ASBMR Three Year Symposia

美国骨与矿物质研究协会（ASBMR）是美国最大的专业、科学和 医学协会成立，汇集临床和实验室为基础的科学家谁是参与 研究骨骼，矿物和肌肉骨骼科学，有一个成功的历史，进行年度专题 自2002年以来，由NIH R13赠款资助的会议。2015年，ASBMR获得了为期三年的R13， 涵盖2016- 2018年的三场会前专题讨论会。该申请寻求为期三年的R13资助， 通过专注于以下三个具体的科学研究领域，推进肌肉骨骼疾病领域的研究： 2019年、2010年和2021年：1）“肌肉：通往新治疗目标的道路”; 2）“种子和土壤： 骨肿瘤的治疗靶点”; 3）“老化骨骼的生物学：对骨折的影响 预防”。这三个领域涵盖了一系列共同导致主要临床发病率的主题 残疾和死亡率。R13的总体目标是促进进一步的进步， 通过汇集每个国家最好的研究人员，改善肌肉骨骼疾病的患者护理。 将与ASBMR年会同时举行的三个专题讨论会。三场专题讨论会 将审查每个主题领域的最新技术，与与会者交换意见，并激发 年轻人和成熟的研究人员之间的互动。对于三个专题讨论会，与会者将 鼓励参加随后的ASBMR年会，以获得更多的机会与 肌肉骨骼研究者所有三年的比赛都是由组委会制定的 在头两年里有坚定的演讲者和主席。议程包括建立和年轻 调查员，有男有女。由于ASBMR成员中约有一半来自美国以外，我们还 包括一些重要国际演讲者。每次会议结束时， 计划让年轻的调查人员和更资深的发言者在会上直接互动。在 2019年，研讨会将评估新兴的肌肉基础科学（自噬肌肉，线粒体， 干细胞和卫星细胞），转化研究，包括开发潜在的治疗靶点， 临床研究2020年，研讨会将重点关注骨骼贡献的最新进展 骨微环境的病理生理学，预防和治疗癌症。2021年研讨会 将汇集老年科学和骨骼生物学的专家，以提高我们对生物老化的理解 这是治疗干预的目标，以增加健康寿命并将其应用于老龄化， 骷髅

The American Society for Bone and Mineral Research (ASBMR), the largest professional, scientific and medical society established to bring together clinical and laboratory-based scientists who are involved in the study of bone, mineral and musculoskeletal science, has had a successful history of conducting annual topical meetings funded by single year NIH R13 grants since 2002. In 2015, ASBMR received a three-year R13 to cover three pre-meeting symposia for 2016-2018.This application seeks funding for a three-year R13 grant to advance the field of musculoskeletal diseases by focusing on three specific areas of scientific research in 2019, 2010 and 2021: 1) “Muscle: The Path Forward to New Therapeutic Targets”; 2) “The Seed and Soil: Therapeutic Targets for Cancer in Bone”; 3) “Biology of the Aging Skeleton: Implications for Fracture Prevention”. These three areas cover a range of topics that collectively contribute to major clinical morbidity disability and mortality. The overall objective of this R13 is to stimulate further advances that will result in improved patient care for musculoskeletal diseases by bringing together the best researchers for each of the three symposia that will be held in conjunction with the ASBMR Annual Meetings. Each of the three symposia will review the state of the art in each topic area, exchanging ideas with attendees, and stimulating the interaction between young and established researchers. For each of the three symposia, attendees will be encouraged to attend the subsequent ASBMR Annual Meetings for additional opportunities to interact with musculoskeletal researchers. Agendas for all three years have been developed by an organizing committee with committed speakers and chairs for the first two years. The agendas include established and young investigators, women and men. Since about half of ASBMR membership is from outside the US, we also include a number of key international speakers. At the end of each meeting, a “dine-around” evening is planned to allow direct interaction between young investigators and more senior speakers at the meeting. In 2019, the symposium will appraise the emerging basic science of muscle (autophagy muscle, mitochondria, stem and satellite cells), translational research including development of potential therapeutic targets and to clinical research. In 2020, the symposium will focus on recent advances in the contributions of the bone microenvironment to the pathophysiology, prevention and treatment of cancer in bone. The 2021 symposium will bring together experts in geroscience and skeletal biology to enhance our understanding of biological aging that is being targeted by therapeutic interventions to increase health span and apply them to the aging skeleton.